Rabbit anti-Human, Mouse KDM2B Polyclonal Antibody | anti-KDM2B antibody

KDM2B Rabbit pAb

Cat. Num. AAA4755042

• Gene Names: KDM2B; CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
• Reactivity: Human, Mouse
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: KDM2B; Polyclonal Antibody; KDM2B Rabbit pAb; lysine demethylase 2B; CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B; anti-KDM2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-KDM2B antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:5000-1:10,000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human KDM2B
• Conjugation: Unconjugated
• Molecular Function: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using 164340(KDM2B Antibody) at dilution 1/40. (Original magnification: ×200))

Related Product Information for anti-KDM2B antibody

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

Product Categories/Family for anti-KDM2B antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 54112380
• NCBI GeneID: 84678
• NCBI Accession #: NP_001005366.1
• NCBI GenBank Nucleotide #: NM_001005366.1
• UniProt Accession #: Q8NHM5; Q8NCI2; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75; A8MRS1
• Molecular Weight: 144,769 Da
• NCBI Official Full Name: lysine-specific demethylase 2B isoform b
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 2B
• NCBI Official Symbol: KDM2B
• NCBI Official Synonym Symbols: CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
• NCBI Protein Information: lysine-specific demethylase 2B; F-box protein FBL10; F-box/LRR-repeat protein 10; CXXC-type zinc finger protein 2; protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B; F-box and leucine-rich repeat protein 10; jumonji C domain-containi
• UniProt Protein Name: Lysine-specific demethylase 2B
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM2B
• UniProt Synonym Gene Names: CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Protein JEMMA
• UniProt Entry Name: KDM2B_HUMAN

NCBI Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.27; Oxidoreductase; Nucleolus; Demethylase; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: nucleoplasm; nucleolus; PcG protein complex; nucleus

Molecular Function: rRNA binding; protein binding; histone demethylase activity; DNA binding; zinc ion binding; histone demethylase activity (H3-K36 specific)

Biological Process: midbrain-hindbrain boundary morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; fourth ventricle development; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; midbrain development; forebrain development; spermatogenesis; embryonic camera-type eye morphogenesis; negative regulation of neuron apoptosis; lateral ventricle development; hindbrain development