Goat KCNQ3 Polyclonal Antibody | anti-KCNQ3 antibody
Goat anti-KCNQ3 Antibody
Western Blot: Preliminary experiments gave an approx.23kDa band in Human Brain (Cerebral Cortex, Amygdala, Hippocampus) lysates after 0.3ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 96.7kDa according to NP_004510.1. The 23kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
Kv7.3: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Defects in KCNQ3 are the cause of benign familial neonatal seizures type 2 (BFNS2). A disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.3/KCNQ3 sub-subfamily.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: cell surface; plasma membrane; voltage-gated potassium channel complex
Molecular Function: calmodulin binding; delayed rectifier potassium channel activity; potassium channel activity; voltage-gated potassium channel activity
Biological Process: membrane hyperpolarization; potassium ion transport; synaptic transmission
Disease: Seizures, Benign Familial Neonatal, 2
Research Articles on KCNQ3
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Product Notes
The KCNQ3 kcnq3 (Catalog #AAA421667) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-KCNQ3 Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's KCNQ3 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments gave an approx.23kDa band in Human Brain (Cerebral Cortex, Amygdala, Hippocampus) lysates after 0.3ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 96.7kDa according to NP_004510.1. The 23kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the KCNQ3 kcnq3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: SDSVWTPSNK PI. It is sometimes possible for the material contained within the vial of "KCNQ3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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