Rabbit KCNN3 Polyclonal Antibody | anti-KCNN3 antibody

KCNN3 Polyclonal Antibody

Cat. Num. AAA2561986

• Gene Names: KCNN3; SK3; hSK3; SKCA3; KCa2.3
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: KCNN3; Polyclonal Antibody; KCNN3 Polyclonal Antibody; hSK3; KCa2.3; Kcnn3; Potassium calcium activated channel subfamily N member 3; Potassium channel calcium activated intermediate/small conductance subfamily N alpha member 3; Potassium channel; Calcium activated; Intermediate/small conductance; Subfamily N; Member 3; Potassium intermediate/small conductance calcium activated channel subfamily N member 3; SK3; SKCa 3; SKCa3; Small conductance calcium-activated potassium channel protein 3; anti-KCNN3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 1.8mg/mL (varies by lot)
• Sequence Length: 746

• Applicable Applications for anti-KCNN3 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50-1:300; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human KCNN3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using KCNN3 Polyclonal Antibody at dilution of 1:60(×200))

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human tonsil tissue using KCNN3 Polyclonal Antibody at dilution of 1:60(×200))

Related Product Information for anti-KCNN3 antibody

KCNN3 (Potassium Calcium-Activated Channel Subfamily N Member 3) is a Protein Coding gene. Diseases associated with KCNN3 include Spinocerebellar Ataxia 2 and Bipolar Disorder. Among its related pathways are Insulin secretion and Transmission across Chemical Synapses. GO annotations related to this gene include protein heterodimerization activity and calcium-activated potassium channel activity. An important paralog of this gene is KCNN2.Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-KCNN3 antibody

Neuroscience; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 323276683
• NCBI GeneID: 3782
• NCBI Accession #: NP_001191016.1
• NCBI GenBank Nucleotide #: NP_001191016.1
• UniProt Accession #: Q9UGI6
• NCBI Official Full Name: small conductance calcium-activated potassium channel protein 3 isoform c
• NCBI Official Synonym Full Names: potassium calcium-activated channel subfamily N member 3
• NCBI Official Symbol: KCNN3
• NCBI Official Synonym Symbols: SK3; hSK3; SKCA3; KCa2.3
• NCBI Protein Information: small conductance calcium-activated potassium channel protein 3
• UniProt Protein Name: Small conductance calcium-activated potassium channel protein 3
• Protein Family: Small conductance calcium-activated potassium channel protein
• UniProt Gene Name: KCNN3
• UniProt Synonym Gene Names: K3; SK3; SKCa 3; SKCa3
• UniProt Entry Name: KCNN3_HUMAN

NCBI Description

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Uniprot Description

Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Subunit structure: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Polymorphism: The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in the population.

Sequence similarities: Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily.