Western Blot (WB)
(All lanes : Anti-KCNMB2 Antibody (N-term) at 1:2000 dilutionLane 1: human brain lysateLane 2: human heart lysateLane 3: human kidney lysateLane 4: HepG2 whole cell lysateLane 5: mouse brain lysateLane 6: rat brain lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit KCNMB2 Polyclonal Antibody | anti-KCNMB2 antibody
KCNMB2 Antibody (N-term)
Predicted: Dog, Chicken
Predicted: Dog, Chicken
Western Blot (WB)
(All lanes : Anti-KCNMB2 Antibody (N-term) at 1:2000 dilutionLane 1: human brain lysateLane 2: human heart lysateLane 3: human kidney lysateLane 4: HepG2 whole cell lysateLane 5: mouse brain lysateLane 6: rat brain lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(All lanes : Anti-KCNMB2 Antibody (N-term) at 1:2000 dilutionLane 1: human brain lysateLane 2: human heart lysateLane 3: human kidney lysateLane 4: HepG2 whole cell lysateLane 5: mouse brain lysateLane 6: rat brain lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 27 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Background: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
NCBI and Uniprot Product Information
NCBI Description
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
Uniprot Description
KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q26.32
Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane
Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; ion channel inhibitor activity
Biological Process: synaptic transmission; regulation of action potential; regulation of vasoconstriction; generation of action potential; detection of calcium ion; blood coagulation; potassium ion transport
Research Articles on KCNMB2
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Product Notes
The KCNMB2 kcnmb2 (Catalog #AAA9232119) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCNMB2 Antibody (N-term) reacts with Human, Mouse, Rat Predicted: Dog, Chicken and may cross-react with other species as described in the data sheet. AAA Biotech's KCNMB2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:2000. Researchers should empirically determine the suitability of the KCNMB2 kcnmb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNMB2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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