Rabbit anti-Human KCNK4 Polyclonal Antibody | anti-KCNK4 antibody

KCNK4 Polyclonal Antibody

Cat. Num. AAA9132127

• Gene Names: KCNK4; TRAAK; K2p4.1; TRAAK1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: KCNK4; Polyclonal Antibody; KCNK4 Polyclonal Antibody; K2p4.1; TRAAK; TRAAK1; anti-KCNK4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 393

• Applicable Applications for anti-KCNK4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500 - 2000
• Immunogen: Recombinant protein of human KCNK4
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of HepG2 cells, using KCNK4 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.)

Related Product Information for anti-KCNK4 antibody

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802.

Product Categories/Family for anti-KCNK4 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 13124080
• NCBI GeneID: 50801
• UniProt Accession #: Q9NYG8; Q96T94; B5TJL1
• Molecular Weight: 43kDa
• NCBI Official Full Name: Potassium channel subfamily K member 4
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 4
• NCBI Official Symbol: KCNK4
• NCBI Official Synonym Symbols: TRAAK; K2p4.1; TRAAK1
• NCBI Protein Information: potassium channel subfamily K member 4
• UniProt Protein Name: Potassium channel subfamily K member 4
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: KCNK4
• UniProt Synonym Gene Names: TRAAK; Two pore K(+) channel KT4.1

NCBI Description

This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipid membrane. This protein is expressed primarily in neural tissues and may be involved in regulating the noxious input threshold in dorsal root ganglia neurons. Alternate splicing results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream testis expressed 40 (TEX40) gene, as represented in GeneID: 106780802. [provided by RefSeq, Nov 2015]

Uniprot Description

KCNK4: Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: potassium channel activity

Biological Process: detection of mechanical stimulus involved in sensory perception of touch; potassium ion transport; sensory perception of pain; sensory perception of temperature stimulus