Rabbit anti-Human, Mouse KCNIP4 Polyclonal Antibody | anti-KCNIP4 antibody

KCNIP4, NT (KCNIP4, CALP, KCHIP4, Kv channel-interacting protein 4, A-type potassium channel modulatory protein 4, Calsenilin-like protein, Potassium channel-interacting protein 4) (FITC)

Cat. Num. AAA6312470

• Gene Names: KCNIP4; CALP; KCHIP4
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNIP4; Polyclonal Antibody; NT (KCNIP4; CALP; KCHIP4; Kv channel-interacting protein 4; A-type potassium channel modulatory protein 4; Calsenilin-like protein; Potassium channel-interacting protein 4) (FITC); Potassium channel-interacting protein 4; anti-KCNIP4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-KCNIP4 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNIP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human KCNIP4.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNIP4 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the KCNIP4 antibody detected the KCNIP4 protein (arrow).)

Related Product Information for anti-KCNIP4 antibody

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Product Categories/Family for anti-KCNIP4 antibody

Antibodies; Ion Channel

References

Horinouchi, M., et al. Pediatr Hematol Oncol 27(5):344-354(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Lin, L., et al. Mol. Cell. Neurosci. 43(3):315-325(2010). Ding, H., et al. Stroke 41(1):177-180(2010). Trynka, G., et al. Gut 58(8):1078-1083(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 78190488
• NCBI GeneID: 80333
• NCBI Accession #: NP_001030176.1; NP_079497.2
• NCBI GenBank Nucleotide #: NM_001035004.1
• UniProt Accession #: Q6PIL6; Q3YAB8; Q3YAB9; Q3YAC0; Q3YAC1; Q3YAC2; Q4W5G8; Q8NEU0; Q9BWT2; Q9H294; Q9H2A4
• Molecular Weight: 28,729 Da
• NCBI Official Full Name: Kv channel-interacting protein 4 isoform 3
• NCBI Official Synonym Full Names: Kv channel interacting protein 4
• NCBI Official Symbol: KCNIP4
• NCBI Official Synonym Symbols: CALP; KCHIP4
• NCBI Protein Information: Kv channel-interacting protein 4; calsenilin-like protein; potassium channel interacting protein 4; potassium channel-interacting protein 4; a-type potassium channel modulatory protein 4
• UniProt Protein Name: Kv channel-interacting protein 4
• Protein Family: Kv channel-interacting protein
• UniProt Gene Name: KCNIP4
• UniProt Synonym Gene Names: CALP; KCHIP4; KChIP4

NCBI Description

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.