Western Blot (WB)
(KCNE2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNE2 antibody detected the KCNE2 protein (arrow).)
Rabbit anti-Human KCNE2 Polyclonal Antibody | anti-KCNE2 antibody
KCNE2 Antibody (C-term)
Western Blot (WB)
(KCNE2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNE2 antibody detected the KCNE2 protein (arrow).)
Western Blot (WB)
(KCNE2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the KCNE2 antibody detected the KCNE2 protein (arrow).)
complex class of voltage-gated ion channels from both functional
and structural standpoints. Their diverse functions include
regulating neurotransmitter release, heart rate, insulin secretion,
neuronal excitability, epithelial electrolyte transport, smooth
muscle contraction, and cell volume. This gene encodes a member of
the potassium channel, voltage-gated, isk-related subfamily. This
member is a small integral membrane subunit that assembles with the
KCNH2 gene product, a pore-forming protein, to alter its function.
This gene is expressed in heart and muscle and the gene mutations
are associated with cardiac arrhythmia.
Albert, C.M., et al. Circ Arrhythm Electrophysiol 3(3):222-229(2010)
Subbiah, R.N., et al. Can J Cardiol 26(4):208-212(2010)
Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010)
Roepke, T.K., et al. PLoS ONE 5 (7), E11451 (2010) :
NCBI and Uniprot Product Information
NCBI Description
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
Uniprot Description
KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: voltage-gated potassium channel complex; cell surface; lysosome; plasma membrane
Molecular Function: protein homodimerization activity; potassium channel regulator activity; delayed rectifier potassium channel activity; inward rectifier potassium channel activity
Biological Process: tongue development; potassium ion import; aging
Disease: Long Qt Syndrome 6; Atrial Fibrillation, Familial, 4
Research Articles on KCNE2
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Product Notes
The KCNE2 kcne2 (Catalog #AAA9212675) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 79-107. The KCNE2 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNE2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the KCNE2 kcne2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNE2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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