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Immunohistochemistry (IHC) (Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))

Rabbit KCNC1/Kv3.1 Polyclonal Antibody | anti-KCNC1/Kv3.1 antibody

Anti-KCNC1/Kv3.1 Antibody (Internal)

Gene Names
KCNC1; KV4; EPM7; NGK2; KV3.1
Reactivity
Human
Predicted: Rabbit, Mouse, Bovine, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunoaffinity Purified
Synonyms
KCNC1/Kv3.1; Polyclonal Antibody; Anti-KCNC1/Kv3.1 Antibody (Internal); Mouse Monoclonal [clone S16B-8]; KCNC1; KShIIIB; KV3.1; Raw2; Shaw22; KV4; NGK2; anti-KCNC1/Kv3.1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Predicted: Rabbit, Mouse, Bovine, Rat
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of Kv3.1 protein.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
Sequence Length
511
Applicable Applications for anti-KCNC1/Kv3.1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes
IHC-P: 1:100
WB: 1:500-1:1000
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the central region of human Kv3.1.
Conjugation
Unconjugated
Epitope
Internal
Preparation and Storage
Store at -20 degree C.
Aliquot to avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC) (Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of Kv3.1 expression in HepG2 (A); rat brain (B) whole cell lysates.)

Western Blot (WB) (Western blot analysis of Kv3.1 expression in HepG2 (A); rat brain (B) whole cell lysates.)
Related Product Information for anti-KCNC1/Kv3.1 antibody
Mediates the voltage-dependent potassium ion permeability of excitablemembranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms apotassium-selective channel through which potassium ions may pass inaccordance with their electrochemical gradient.
Product Categories/Family for anti-KCNC1/Kv3.1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
65,871 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily C member 1 isoform 2
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily C member 1
NCBI Official Symbol
KCNC1
NCBI Official Synonym Symbols
KV4; EPM7; NGK2; KV3.1
NCBI Protein Information
potassium voltage-gated channel subfamily C member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily C member 1
UniProt Gene Name
KCNC1

NCBI Description

This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]

Uniprot Description

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.

Research Articles on KCNC1/Kv3.1

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Product Notes

The KCNC1/Kv3.1 kcnc1 (Catalog #AAA2401644) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-KCNC1/Kv3.1 Antibody (Internal) reacts with Human Predicted: Rabbit, Mouse, Bovine, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's KCNC1/Kv3.1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB). IHC-P: 1:100 WB: 1:500-1:1000. Researchers should empirically determine the suitability of the KCNC1/Kv3.1 kcnc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNC1/Kv3.1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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