Rabbit anti-Human KCNB2 Polyclonal Antibody | anti-KCNB2 antibody

KCNB2, NT (KCNB2, Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv2.2) (FITC)

Cat. Num. AAA6312294

• Gene Names: KCNB2; KV2.2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNB2; Polyclonal Antibody; NT (KCNB2; Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel subunit Kv2.2) (FITC); Voltage-gated potassium channel subunit Kv2.2; anti-KCNB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-KCNB2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the N-terminal region of human KCNB2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNB2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the KCNB2 antibody detected the KCNB2 protein (arrow).)

Related Product Information for anti-KCNB2 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells.

Product Categories/Family for anti-KCNB2 antibody

Antibodies; Ion Channel

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010). Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009). Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008). Wu, C., et al. Proteomics 7(11):1775-1785(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 27436974
• NCBI GeneID: 9312
• NCBI Accession #: NP_004761.2
• NCBI GenBank Nucleotide #: NM_004770.2
• UniProt Accession #: Q92953; Q7Z7D0; Q9BXD3
• Molecular Weight: 102,563 Da
• NCBI Official Full Name: potassium voltage-gated channel subfamily B member 2
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily B member 2
• NCBI Official Symbol: KCNB2
• NCBI Official Synonym Symbols: KV2.2
• NCBI Protein Information: potassium voltage-gated channel subfamily B member 2
• UniProt Protein Name: Potassium voltage-gated channel subfamily B member 2
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNB2

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

Uniprot Description

Kv2.2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: dendrite; integral component of membrane; perikaryon; plasma membrane; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; protein heterodimerization activity; voltage-gated potassium channel activity

Biological Process: potassium ion transport; protein homooligomerization; regulation of smooth muscle contraction