Western Blot (WB)
(Anti- KCNA5 Picoband antibody, MBS178295, Western blottingAll lanes: Anti KCNA5 (MBS178295) at 0.5ug/mlLane 1: 293T Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: PANC Whole Cell Lysate at 40ugPredicted bind size: 67KDObserved bind size: 67KD )
anti-Human KCNA5 Polyclonal Antibody | anti-KCNA5 antibody
Anti-KCNA5 Antibody
Western Blot (WB)
(Anti- KCNA5 Picoband antibody, MBS178295, Western blottingAll lanes: Anti KCNA5 (MBS178295) at 0.5ug/mlLane 1: 293T Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: PANC Whole Cell Lysate at 40ugPredicted bind size: 67KDObserved bind size: 67KD )
Western Blot (WB)
(Anti- KCNA5 Picoband antibody, MBS178295, Western blottingAll lanes: Anti KCNA5 (MBS178295) at 0.5ug/mlLane 1: 293T Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: PANC Whole Cell Lysate at 40ugPredicted bind size: 67KDObserved bind size: 67KD )
Background: Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.
NCBI and Uniprot Product Information
NCBI Description
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]
Uniprot Description
Kv1.5: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Defects in KCNA5 are the cause of familial atrial fibrillation type 7 (ATFB7). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: caveola; cytosol; endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; intracellular canaliculus; lipid raft; perinuclear region of cytoplasm; plasma membrane; voltage-gated potassium channel complex; Z disc
Molecular Function: alpha-actinin binding; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; potassium channel inhibitor activity; protein binding; protein kinase binding; receptor binding
Biological Process: membrane hyperpolarization; negative regulation of potassium ion transport; Notch signaling pathway; potassium ion homeostasis; potassium ion transport; protein homooligomerization; reduction of cytosolic calcium ion concentration; regulation of insulin secretion; regulation of membrane potential; regulation of potassium ion transport; regulation of vasoconstriction; response to hydrogen peroxide; response to hyperoxia; response to hypoxia; response to mechanical stimulus; response to organic substance
Disease: Atrial Fibrillation, Familial, 7
Research Articles on KCNA5
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Product Notes
The KCNA5 kcna5 (Catalog #AAA178295) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-KCNA5 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNA5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the KCNA5 kcna5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNA5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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