Rabbit KChIP3 Polyclonal Antibody | anti-KChIP3 antibody

KChIP3 Rabbit pAb

Cat. Num. AAA8808414

• Gene Names: KCNIP3; CSEN; DREAM; KCHIP3
• Reactivity: Human, Rat, Mouse
• Synonyms: KChIP3; Polyclonal Antibody; KChIP3 Rabbit pAb; KCNIP3; A type potassium channel modulatory protein 3; anti-KChIP3 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: PBS with 0.02% sodium azide and 50% glycerol pH7.4.
• Concentration: 1mg/ml (varies by lot)

• Species: Human
• Immunogen: Synthetic Peptide
• Preparation and Storage: Store at -20 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using KChIP3 (EA305) Rabbit pAb diluted at 1:200.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using KChIP3 (EA305)Rabbit pAb diluted at 1:200.)

NCBI and Uniprot Product Information

• NCBI GI #: 78190495
• NCBI GeneID: 30818
• NCBI Accession #: NP_001030086.1
• NCBI GenBank Nucleotide #: NM_001034914.1
• UniProt Accession #: Q9Y2W7; Q3YAC3; Q3YAC4; Q53TJ5; Q96T40; Q9UJ84; Q9UJ85; H7BY46
• Molecular Weight: 29,231 Da
• NCBI Official Full Name: calsenilin isoform 2
• NCBI Official Synonym Full Names: Kv channel interacting protein 3, calsenilin
• NCBI Official Symbol: KCNIP3
• NCBI Official Synonym Symbols: CSEN; DREAM; KCHIP3
• NCBI Protein Information: calsenilin; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor
• UniProt Protein Name: Calsenilin
• UniProt Gene Name: KCNIP3
• UniProt Synonym Gene Names: CSEN; DREAM; KCHIP3; DREAM; KChIP3
• UniProt Entry Name: CSEN_HUMAN

NCBI Description

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

calsenilin: a small calcium-binding protein. Member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Modulates K4 voltage-gated potassium channels. May regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Also functions as a calcium-regulated transcriptional repressor, and to interact with presenilins. May play a role in the regulation of PSEN2 proteolytic processing.

Protein type: Calcium-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q21.1

Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; endoplasmic reticulum; dendrite; nerve terminal; nucleus; cytosol

Molecular Function: protein C-terminus binding; potassium channel regulator activity; DNA binding; potassium channel activity; sequence-specific DNA binding; voltage-gated ion channel activity; calcium ion binding; transcription corepressor activity; calcium-dependent protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; intracellular protein transport; behavioral response to pain; transcription, DNA-dependent; apoptosis; regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; sensory perception of pain; signal transduction