Rabbit anti-Human KATNB1 Polyclonal Antibody | anti-KATNB1 antibody

KATNB1, ID (KATNB1, Katanin p80 WD40-containing subunit B1, p80 katanin) (MaxLight 650)

Cat. Num. AAA6312134

• Gene Names: KATNB1; KAT
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KATNB1; Polyclonal Antibody; ID (KATNB1; Katanin p80 WD40-containing subunit B1; p80 katanin) (MaxLight 650); p80 katanin; anti-KATNB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-KATNB1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KATNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the Central region of human KATNB1.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-KATNB1 antibody

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.

Product Categories/Family for anti-KATNB1 antibody

Antibodies; Proteins

References

Olson, J.E., et al. Breast Cancer Res. Treat. (2010). In press: Cummings, C.M., et al. J. Biol. Chem. 284(17):11663-11675(2009). Sudo, H., et al. Hum. Mol. Genet. 17(16):2524-2540(2008). Olsen, J.V., et al. Cell 127(3):635-648(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 83779014
• NCBI GeneID: 10300
• NCBI Accession #: NP_005877.2
• NCBI GenBank Nucleotide #: NM_005886.2
• UniProt Accession #: Q9BVA0; O60620; A6NCG6
• Molecular Weight: 72,334 Da
• NCBI Official Full Name: katanin p80 WD40 repeat-containing subunit B1
• NCBI Official Synonym Full Names: katanin p80 (WD repeat containing) subunit B 1
• NCBI Official Symbol: KATNB1
• NCBI Official Synonym Symbols: KAT
• NCBI Protein Information: katanin p80 WD40 repeat-containing subunit B1; p80 katanin; katanin (80 kDa); katanin p80 subunit B1; katanin p80 WD40-containing subunit B1; katanin p80 (WD40-containing) subunit B 1
• UniProt Protein Name: Katanin p80 WD40 repeat-containing subunit B1
• Protein Family: KATNB1-like protein
• UniProt Gene Name: KATNB1
• UniProt Synonym Gene Names: Katanin p80 subunit B1
• UniProt Entry Name: KTNB1_HUMAN

NCBI Description

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]

Uniprot Description

KATNB1: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Belongs to the WD repeat KATNB1 family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: microtubule cytoskeleton; spindle pole; microtubule; centrosome; growth cone; cell soma; membrane; axon; katanin complex; cytoplasm; plasma membrane; midbody; nucleus

Molecular Function: dynein binding; protein heterodimerization activity; microtubule binding; microtubule-severing ATPase activity

Biological Process: positive regulation of microtubule depolymerization; cell division; negative regulation of microtubule depolymerization; metabolic process; microtubule severing; mitotic chromosome movement towards spindle pole; protein targeting

Disease: Lissencephaly 6, With Microcephaly