Rabbit anti-Human KANK2 Polyclonal Antibody | anti-KANK2 antibody

KANK2, ID (KANK2, ANKRD25, KIAA1518, MXRA3, SIP, KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein) (FITC)

Cat. Num. AAA6312063

• Gene Names: KANK2; SIP; MXRA3; PPKWH; NPHS16; ANKRD25
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KANK2; Polyclonal Antibody; ID (KANK2; ANKRD25; KIAA1518; MXRA3; SIP; KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein) (FITC); SRC-1-interacting protein; anti-KANK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 859

• Applicable Applications for anti-KANK2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-493 amino acids from the Central region of human KANK2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KANK2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the KANK2 antibody detected the KANK2 protein (arrow).)

Related Product Information for anti-KANK2 antibody

ANKRD25 contains 5 ANK repeats. It is strongly expressed in cervix, colon, heart, kidney and lung.

Product Categories/Family for anti-KANK2 antibody

Antibodies; KIAA; orf

References

Zhu, Y., et al. Biochim. Biophys. Acta 1780(2):128-133(2008). Zhang, Y., et al. EMBO J. 26(11):2645-2657(2007). Olsen, J.V., et al. Cell 127(3):635-648(2006). Wistow, G., et al. Mol. Vis. 8, 205-220 (2002).

NCBI and Uniprot Product Information

• NCBI GI #: 258613875
• NCBI GeneID: 25959
• NCBI Accession #: NP_056308.3; NP_001129663.1
• NCBI GenBank Nucleotide #: NP_056308.3
• UniProt Accession #: Q63ZY3
• NCBI Official Full Name: KN motif and ankyrin repeat domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: KN motif and ankyrin repeat domains 2
• NCBI Official Symbol: KANK2
• NCBI Official Synonym Symbols: SIP; MXRA3; PPKWH; NPHS16; ANKRD25
• NCBI Protein Information: KN motif and ankyrin repeat domain-containing protein 2
• UniProt Protein Name: KN motif and ankyrin repeat domain-containing protein 2
• Protein Family: KN motif and ankyrin repeat domain-containing protein
• UniProt Gene Name: KANK2
• UniProt Synonym Gene Names: ANKRD25; KIAA1518; MXRA3; SIP; SIP; SRC-interacting protein
• UniProt Entry Name: KANK2_HUMAN

NCBI Description

This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]

Uniprot Description

ANKRD25: a mammalian growth regulatory protein containing five Ankyrin repeats, common protein-protein interaction motifs. Ankyrin repeats are found in proteins with diverse functions including transcriptional initiators, cell-cycle regulators, cytoskeletal, and ion transporters. Three alternatively spliced isoforms have been described.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: mitochondrion; cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; apoptosis; negative regulation of programmed cell death; negative regulation of transcription from RNA polymerase II promoter; negative regulation of estrogen receptor signaling pathway

Disease: Palmoplantar Keratoderma And Woolly Hair