Rabbit anti-Human JTV1 Polyclonal Antibody | anti-JTV1 antibody

JTV1, ID (Aminoacyl tRNA Synthase Complex-interacting Multifunctional Protein 2, Multisynthetase Complex Auxiliary Component p38, Protein JTV-1, PRO0992) (MaxLight 650)

Cat. Num. AAA6483840

• Gene Names: AIMP2; P38; JTV1; JTV-1; PRO0992
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: JTV1; Polyclonal Antibody; ID (Aminoacyl tRNA Synthase Complex-interacting Multifunctional Protein 2; Multisynthetase Complex Auxiliary Component p38; Protein JTV-1; PRO0992) (MaxLight 650); anti-JTV1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human JTV1.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-JTV1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:50-1:100; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the center region of human JTV1 (KLH).
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-JTV1 Antibody (Center) in NCI-H460 cell line lysates (35ug/lane).JTV1(arrow) was detected using the purified Pab.)

Western Blot (WB)

(Western blot analysis of JTV1 (arrow) using rabbit polyclonal JTV1 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the JTV1 gene.)

Product Categories/Family for anti-JTV1 antibody

Antibodies; Proteins

References

1. Nicolaides N.C., Kinzler K.W., Vogelstein B.Genomics 29:329-334(1995). 2. Kim M.J., Park B.-J., Kang Y.-S., Kim H.J., Park J.-H., Kang J.W., Lee S.W., Nat. Genet. 34:330-336(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 11125770
• NCBI GeneID: 7965
• NCBI Accession #: NP_006294
• NCBI GenBank Nucleotide #: NM_006303.3
• UniProt Accession #: Q13155; Q75MR1; Q96CZ5; Q9P1L2
• Molecular Weight: Predicted: 35 kDa; ; Observed: 36 kDa
• NCBI Official Full Name: aminoacyl tRNA synthase complex-interacting multifunctional protein 2
• NCBI Official Synonym Full Names: aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
• NCBI Official Symbol: AIMP2
• NCBI Official Synonym Symbols: P38; JTV1; JTV-1; PRO0992
• NCBI Protein Information: aminoacyl tRNA synthase complex-interacting multifunctional protein 2; protein JTV-1; ARS-interacting multi-functional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38
• UniProt Protein Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
• UniProt Gene Name: AIMP2
• UniProt Synonym Gene Names: JTV1
• UniProt Entry Name: AIMP2_HUMAN

NCBI Description

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]

Uniprot Description

JTV1: Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: membrane; nucleus; cytosol

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; tRNA aminoacylation for protein translation; positive regulation of protein ubiquitination; apoptosis; gene expression