Rabbit anti-Human JAKMIP1 Polyclonal Antibody | anti-JAKMIP1 antibody

JAKMIP1 (Janus Kinase and Microtubule Interacting Protein 1, JAMIP1, FLJ31564, GABA-B Receptor-binding Protein, GABABRBP, Multiple alpha-helices and RNA-linker Protein 1, MARLIN1, Marlin-1) (AP)

Cat. Num. AAA6483722

• Gene Names: JAKMIP1; JAMIP1; MARLIN1; Gababrbp
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: JAKMIP1; Polyclonal Antibody; JAKMIP1 (Janus Kinase and Microtubule Interacting Protein 1; JAMIP1; FLJ31564; GABA-B Receptor-binding Protein; GABABRBP; Multiple alpha-helices and RNA-linker Protein 1; MARLIN1; Marlin-1) (AP); anti-JAKMIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human JAKMIP1.
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-JAKMIP1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-1:500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the center region of human JAKMIP1 (KLH).
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: May be stored at 4 degree C for short-term only. Do not freeze alkaline phosphatase conjugates which could result in a substantial loss of enzymatic activity. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of JAKMIP1 Antibody (Center) in 293 cell line lysates (35ug/lane). JAKMIP1 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human brain tissue reacted with JAKMIP1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Product Categories/Family for anti-JAKMIP1 antibody

Antibodies; Protein Kinases

References

1. Jin, J., et.al., Curr. Biol. 14(16), 1436-1450 (2004). 2. Steindler, C., et.al., J. Biol. Chem. 279(41), 43168-43177 (2004).

NCBI and Uniprot Product Information

• NCBI GI #: 150456473
• NCBI GeneID: 152789
• NCBI Accession #: NP_001092903.1
• NCBI GenBank Nucleotide #: NM_001099433.1
• UniProt Accession #: Q96N16; Q86Y69; Q8N7G3; A6H2J2; A6H2J3; A6H2J4; A6H2J5; A8MTK6; B4DHZ8; B8ZZR7; D3DVT0
• Molecular Weight: 53,973 Da
• NCBI Official Full Name: janus kinase and microtubule-interacting protein 1 isoform 1
• NCBI Official Synonym Full Names: janus kinase and microtubule interacting protein 1
• NCBI Official Symbol: JAKMIP1
• NCBI Official Synonym Symbols: JAMIP1; MARLIN1; Gababrbp
• NCBI Protein Information: janus kinase and microtubule-interacting protein 1
• UniProt Protein Name: Janus kinase and microtubule-interacting protein 1
• Protein Family: Janus kinase and microtubule-interacting protein
• UniProt Gene Name: JAKMIP1
• UniProt Synonym Gene Names: GABABRBP; JAMIP1; MARLIN1; Marlin-1
• UniProt Entry Name: JKIP1_HUMAN

Uniprot Description

JAKMIP1: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. Belongs to the JAKMIP family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: microtubule; extrinsic to membrane; cytoplasm; ribonucleoprotein complex

Molecular Function: protein binding; RNA binding; kinesin binding; microtubule binding; GABA receptor binding; kinase binding

Biological Process: protein transport; cognition