Rabbit anti-Human ITSN2 Polyclonal Antibody | anti-ITSN2 antibody

ITSN2 Antibody, FITC conjugated

Cat. Num. AAA7051254

• Gene Names: ITSN2; SWA; SWAP; SH3D1B; SH3P18; PRO2015
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: ITSN2; Polyclonal Antibody; ITSN2 Antibody; FITC conjugated; Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein; KIAA1256; SH3D1B; SWAP; anti-ITSN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 1697

• Applicable Applications for anti-ITSN2 antibody: ELISA (EIA)
• Immunogen: Recombinant Human Intersectin-2 protein (940-1209AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: FITC
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9952 / sc-9953 / sc-9954 / sc-9955
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-ITSN2 antibody

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed: 23999003).

NCBI and Uniprot Product Information

• NCBI GI #: 194294521
• NCBI GeneID: 50618
• NCBI Accession #: NP_006268.2
• NCBI GenBank Nucleotide #: NM_006277.2
• UniProt Accession #: Q9NZM3; O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9ULG4
• Molecular Weight: 135,144 Da
• NCBI Official Full Name: intersectin-2 isoform 1
• NCBI Official Synonym Full Names: intersectin 2
• NCBI Official Symbol: ITSN2
• NCBI Official Synonym Symbols: SWA; SWAP; SH3D1B; SH3P18; PRO2015
• NCBI Protein Information: intersectin-2
• UniProt Protein Name: Intersectin-2
• Protein Family: Intersectin
• UniProt Gene Name: ITSN2
• UniProt Synonym Gene Names: KIAA1256; SH3D1B; SWAP
• UniProt Entry Name: ITSN2_HUMAN

NCBI Description

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]

Uniprot Description

ITSN2: adapter protein that contains SH3 domains. Involved in the formation of clathrin-coated vesicles. May function in the induction of T cell antigen receptor (TCR) endocytosis. May provide indirect link between the endocytic membrane traffic and the actin assembly machinery. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: centrosome

Molecular Function: protein binding; SH3/SH2 adaptor activity