Western Blot (WB)
(Host: RabbitTarget Name: ITPR2Sample Type: Fetal Small Intestine lysatesAntibody Dilution: 1.0ug/ml)
Rabbit ITPR2 Polyclonal Antibody | anti-ITPR2 antibody
ITPR2 Antibody - N-terminal region
Western Blot (WB)
(Host: RabbitTarget Name: ITPR2Sample Type: Fetal Small Intestine lysatesAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: ITPR2Sample Type: Fetal Small Intestine lysatesAntibody Dilution: 1.0ug/ml)
Target Description: ITPR2 is a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Uniprot Description
IP3R2: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Most normal tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in the gastrointestinal tract, hepatocytes and exocrine pancreas. Short isoform Is found in skeletal muscle and heart. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA increases calcium release. Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor. Belongs to the InsP3 receptor family. 2 isoforms of the human protein are produced by alternative splicing. The short isoform is found in skeletal muscle and heart.
Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 12p11
Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; plasma membrane; integral to membrane; cell cortex; receptor complex
Molecular Function: calcium ion transmembrane transporter activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity
Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; transport; phospholipase C activation; response to hypoxia; energy reserve metabolic process; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion
Disease: Anhidrosis, Isolated, With Normal Sweat Glands
Research Articles on ITPR2
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Product Notes
The ITPR2 itpr2 (Catalog #AAA3202419) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ITPR2 Antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's ITPR2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ITPR2 itpr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: FRDCLFKVCP MNRYSAQKQY WKAKQAKQGN HTEAALLKKL QHAAELEQKQ. It is sometimes possible for the material contained within the vial of "ITPR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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