Rabbit anti-Human, Mouse ITPKB Polyclonal Antibody | anti-ITPKB antibody

ITPKB (Inositol-trisphosphate 3-kinase B, Inositol 1,4,5-trisphosphate 3-kinase B, IP3 3-kinase B, IP3K B, InsP 3-kinase B)

Cat. Num. AAA648824

• Gene Names: ITPKB; IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ITPKB; Polyclonal Antibody; ITPKB (Inositol-trisphosphate 3-kinase B; Inositol 1; 4; 5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B); Anti -ITPKB (Inositol-trisphosphate 3-kinase B; anti-ITPKB antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ITPKB. Species Crossreactivity: mouse.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRAHSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDALSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDQDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRV

• Applicable Applications for anti-ITPKB antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human ITPKB, aa1-644 (AAH15009.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ITPKB rabbit polyclonal antibody. Western Blot analysis of ITPKB expression in mouse liver.)

Western Blot (WB)

(Western Blot analysis of ITPKB expression in transfected 293T cell line by ITPKB polyclonal antibody. Lane 1: ITPKB transfected lysate (67.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-ITPKB antibody

ITPKB regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.

Product Categories/Family for anti-ITPKB antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 194272161
• NCBI GeneID: 3707
• NCBI Accession #: NP_002212.3
• NCBI GenBank Nucleotide #: NM_002221.3
• UniProt Accession #: P27987; Q5VWL9; Q5VWM0; Q96BZ2; Q96JS1; Q9UH47
• Molecular Weight: 102,376 Da
• NCBI Official Full Name: inositol-trisphosphate 3-kinase B
• NCBI Official Synonym Full Names: inositol-trisphosphate 3-kinase B
• NCBI Official Symbol: ITPKB
• NCBI Official Synonym Symbols: IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
• NCBI Protein Information: inositol-trisphosphate 3-kinase B; IP3K B; IP3 3-kinase B; insP 3-kinase B; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B
• UniProt Protein Name: Inositol-trisphosphate 3-kinase B
• Protein Family: Inositol-trisphosphate 3-kinase
• UniProt Gene Name: ITPKB
• UniProt Synonym Gene Names: IP3 3-kinase B; IP3K B
• UniProt Entry Name: IP3KB_HUMAN

NCBI Description

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

Uniprot Description

Catalytic activity: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulation: IP3K is activated by calmodulin. Form B is much more sensitive to calcium/calmodulin than form A.

Subunit structure: Interacts with DMTN. Ref.9

Sequence similarities: Belongs to the inositol phosphokinase (IPK) family.

Sequence caution: The sequence CAA40491.1 differs from that shown. Reason: Erroneous initiation.