Sheep anti-Human ISLR2 Polyclonal Antibody | anti-ISLR2 antibody
ISLR2 (Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2, SST273)
Gene Names
ISLR2; KIAA1465
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by affinity chromatography.
Synonyms
ISLR2; Polyclonal Antibody; ISLR2 (Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2; SST273); Anti -ISLR2 (Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2; anti-ISLR2 antibody
Host
Sheep
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human ISLR-2, extracellular domain.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Purified by affinity chromatography.
Form/Format
Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
Applicable Applications for anti-ISLR2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in Direct ELISA and Western Blot.
Dilution: Direct ELISA: 0.5-1.0ug/ml detection limit for rhISLR-2 is ~0.2ng/well.
Western Blot: 0.1-0.2ug/ml detection limit for rhISLR-2 is ~5ng/lane under non-reducing and reducing conditions.
Dilution: Direct ELISA: 0.5-1.0ug/ml detection limit for rhISLR-2 is ~0.2ng/well.
Western Blot: 0.1-0.2ug/ml detection limit for rhISLR-2 is ~5ng/lane under non-reducing and reducing conditions.
Immunogen
Recombinant protein corresponding to aa20-590 at the extracellular domain of human ISLR-2, expressed in NS0 cells (Accession # Q6UXK2).
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-ISLR2 antibody
ISLR-2 (Ig-superfamily containing LRR protein 2; also KIAA1465) is a 100-110kD member of the LRR family of proteins. It is expressed on developing motor, sensory and interneurons. Mature human ISLR-2 is 727aa in length. It is a type I transmembrane glycoprotein that contains a 571 aa extracellular domain (ECD) and a 135 aa cytoplasmic region. The ECD shows multiple LRRs (aa50-227) and one Ig-like domain (aa233-371). One alternate splice form may exist that shows a deletion of aa160-570. Over aa20-590, human ISLR-2 is 89% aa identical to both canine and mouse ISLR-2.
Product Categories/Family for anti-ISLR2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
78,990 Da
NCBI Official Full Name
immunoglobulin superfamily containing leucine-rich repeat protein 2
NCBI Official Synonym Full Names
immunoglobulin superfamily containing leucine-rich repeat 2
NCBI Official Symbol
ISLR2
NCBI Official Synonym Symbols
KIAA1465
NCBI Protein Information
immunoglobulin superfamily containing leucine-rich repeat protein 2; OTTHUMP00000174969; leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein
UniProt Protein Name
Immunoglobulin superfamily containing leucine-rich repeat protein 2
UniProt Gene Name
ISLR2
UniProt Synonym Gene Names
KIAA1465; LINX
UniProt Entry Name
ISLR2_HUMAN
Uniprot Description
ISLR2: Required for axon extension during neural development.
Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell surface; Cell development/differentiation
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: cell surface; integral to membrane; plasma membrane
Biological Process: positive regulation of axon extension
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Product Notes
The ISLR2 islr2 (Catalog #AAA618433) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The ISLR2 (Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2, SST273) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ISLR2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Direct ELISA and Western Blot. Dilution: Direct ELISA: 0.5-1.0ug/ml detection limit for rhISLR-2 is ~0.2ng/well. Western Blot: 0.1-0.2ug/ml detection limit for rhISLR-2 is ~5ng/lane under non-reducing and reducing conditions. Researchers should empirically determine the suitability of the ISLR2 islr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ISLR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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