Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse stomach using MBS7606931 (IRS2 antibody) at dilution 1:100)
Rabbit IRS2 Polyclonal Antibody | anti-IRS2 antibody
Anti-IRS2 Antibody
Immunogen Affinity Purified
Immunogen Affinity Purified
IHC: 1:50-1:100
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse stomach using MBS7606931 (IRS2 antibody) at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse stomach using MBS7606931 (IRS2 antibody) at dilution 1:100)
Western Blot (WB)
(rat liver tissue were subjected to SDS PAGE followed by western blot with MBS7606931 (IRS2 antibody) at dilution of 1:1000)
Western Blot (WB)
(rat liver tissue were subjected to SDS PAGE followed by western blot with MBS7606931 (IRS2 antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Uniprot Description
IRS2: May mediate the control of various cellular processes by insulin. Interacts with PHIP.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cytosol; plasma membrane; protein complex
Molecular Function: 1-phosphatidylinositol-3-kinase activity; 14-3-3 protein binding; insulin receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphoinositide 3-kinase binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; Ras guanyl-nucleotide exchange factor activity; signal transducer activity
Biological Process: axon guidance; brain development; cell proliferation; cellular response to glucose stimulus; cellular response to insulin stimulus; glucose metabolic process; insulin receptor signaling pathway; interleukin-7-mediated signaling pathway; lipid homeostasis; mammary gland development; MAPK cascade; negative regulation of B cell apoptotic process; negative regulation of kinase activity; negative regulation of plasma membrane long-chain fatty acid transport; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; positive regulation of B cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin secretion; positive regulation of mesenchymal cell proliferation; positive regulation of protein kinase B signaling; regulation of lipid metabolic process; response to glucose stimulus; signal transduction
Disease: Diabetes Mellitus, Noninsulin-dependent
Research Articles on IRS2
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Product Notes
The IRS2 irs2 (Catalog #AAA7606931) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-IRS2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IRS2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). WB: 1:500-1:2000 IHC: 1:50-1:100. Researchers should empirically determine the suitability of the IRS2 irs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IRS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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