Western Blot (WB)
(NUBPL Antibody (N-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the NUBPL antibody detected the NUBPL protein (arrow).)
Rabbit anti-Human, mouse NUBPL Polyclonal Antibody | anti-NUBPL antibody
NUBPL Antibody (N-term)
Western Blot (WB)
(NUBPL Antibody (N-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the NUBPL antibody detected the NUBPL protein (arrow).)
Western Blot (WB)
(NUBPL Antibody (N-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the NUBPL antibody detected the NUBPL protein (arrow).)
1.6.5.3) is a large mitochondrial inner membrane enzyme consisting
of 45 subunits and 8 iron-sulfur (Fe/S) clusters. NUBPL, or IND1,
is an Fe/ S protein that plays a critical role in the assembly of
respiratory complex I, likely by transferring Fe/S into the
Fe/S-containing complex I subunits (Sheftel et al., 2009 [PubMed
19752196]).
Sheftel, A.D., et al. Mol. Cell. Biol. 29(22):6059-6073(2009)
Volpi, S., et al. Mol. Psychiatry 14(11):1024-1031(2009)
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Mutations in this gene cause mitochondrial complex I deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
NUBPL: Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits. Defects in NUBPL are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the Mrp/NBP35 ATP-binding proteins family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: mitochondrion
Molecular Function: metal ion binding; 4 iron, 4 sulfur cluster binding; ATP binding
Biological Process: mitochondrial respiratory chain complex I assembly
Disease: Mitochondrial Complex I Deficiency
Research Articles on NUBPL
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Product Notes
The NUBPL nubpl (Catalog #AAA9214077) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 40-67. The NUBPL Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's NUBPL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the NUBPL nubpl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NUBPL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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