Rabbit anti-Human IQSEC2 Polyclonal Antibody | anti-IQSEC2 antibody

IQSEC2 (IQ Motif and SEC7 Domain-Containing Protein 2, IQSEC2, KIAA0522) (Biotin)

Cat. Num. AAA6456692

• Gene Names: IQSEC2; MRX1; BRAG1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IQSEC2; Polyclonal Antibody; IQSEC2 (IQ Motif and SEC7 Domain-Containing Protein 2; KIAA0522) (Biotin); anti-IQSEC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IQSEC2. Species Crossreactivity: human
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-IQSEC2 antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa451-484 at the Central region of human IQSEC2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Product Categories/Family for anti-IQSEC2 antibody

Antibodies; KIAA; orf

References

Nagase T., et al. DNA Res. 5:31-39(1998). Ota T., et al. Nat. Genet. 36:40-45(2004). Ross M.T., et al. Nature 434:325-337(2005). Shapovalova Z., et al. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases. Rigbolt K.T., et al. Sci. Signal. 4:RS3-RS3(2011).

NCBI and Uniprot Product Information

• NCBI GI #: 162138911
• NCBI GeneID: 23096
• NCBI Accession #: NP_001104595
• NCBI GenBank Nucleotide #: NM_001111125.2
• UniProt Accession #: Q5JU85; O60275; Q5JUX1; B3KT97; C7SDG1
• Molecular Weight: Predicted: 104; 133; 141; 164 kDa; ; Observed: 140 kDa
• NCBI Official Full Name: IQ motif and SEC7 domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: IQ motif and Sec7 domain 2
• NCBI Official Symbol: IQSEC2
• NCBI Official Synonym Symbols: MRX1; BRAG1
• NCBI Protein Information: IQ motif and SEC7 domain-containing protein 2; brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c
• UniProt Protein Name: IQ motif and SEC7 domain-containing protein 2
• Protein Family: IQ motif and SEC7 domain-containing protein
• UniProt Gene Name: IQSEC2
• UniProt Synonym Gene Names: KIAA0522
• UniProt Entry Name: IQEC2_HUMAN

NCBI Description

This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

IQSEC2: Defects in IQSEC2 are the cause of mental retardation X- linked type 1 (MRX1). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation. Belongs to the BRAG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, ARF; GEFs

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: trans-Golgi network; cell junction; nucleus

Molecular Function: ARF guanyl-nucleotide exchange factor activity

Biological Process: vesicle-mediated transport; regulation of ARF protein signal transduction; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity

Disease: Mental Retardation, X-linked 1