Western Blot (WB)
(IPO7 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).)
Rabbit anti-Human, mouse IPO7 Polyclonal Antibody | anti-IPO7 antibody
IPO7 Antibody (N-term)
Western Blot (WB)
(IPO7 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).)
Western Blot (WB)
(IPO7 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).)
Western Blot (WB)
(IPO7 Antibody (N-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).)
Western Blot (WB)
(IPO7 Antibody (N-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the IPO7 antibody detected the IPO7 protein (arrow).)
Immunohistochemistry (IHC)
(IPO7 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRABP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(IPO7 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervix carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CRABP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
nuclear import of proteins with a classical nuclear localization
signal. The protein encoded by this gene is a member of a class of
approximately 20 potential Ran targets that share a sequence motif
related to the Ran-binding site of importin-beta. Similar to
importin-beta, this protein prevents the activation of Ran's GTPase
by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also
binds directly to nuclear pore complexes where it competes for
binding sites with importin-beta and transportin. This protein has
a Ran-dependent transport cycle and it can cross the nuclear
envelope rapidly and in both directions. At least four importin
beta-like transport receptors, namely importin beta itself,
transportin, RanBP5 and RanBP7, directly bind and import ribosomal
proteins.
Chachami, G., et al. Biochem. Biophys. Res. Commun. 390(2):235-240(2009)
Adeyemo, A., et al. PLoS Genet. 5 (7), E1000564 (2009) :
Zaitseva, L., et al. Retrovirology 6, 11 (2009) :
Yao, X., et al. J. Biol. Chem. 283(33):22867-22874(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Dean, K.A., et al. J. Cell. Sci. 114 (PT 19), 3479-3485 (2001) :
Jakel, S., et al. EMBO J. 18(9):2411-2423(1999)
Paraskeva, E., et al. J. Cell Biol. 145(2):255-264(1999)
Jakel, S., et al. EMBO J. 17(15):4491-4502(1998)
Gorlich, D., et al. J. Cell Biol. 138(1):65-80(1997)
NCBI and Uniprot Product Information
NCBI Description
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
IPO7: a beta importin protein. Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin beta-1 subunit. A receptor for nuclear localization signals (NLS) that promotes translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
Protein type: Nuclear import; Karyopherin; Nuclear export
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: nucleoplasm; membrane; cytoplasm; nuclear pore
Molecular Function: protein binding; histone binding; transporter activity; Ran GTPase binding
Biological Process: viral reproduction; protein import into nucleus; regulation of catalytic activity; innate immune response; signal transduction
Research Articles on IPO7
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Product Notes
The IPO7 ipo7 (Catalog #AAA9208072) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 142-169. The IPO7 Antibody (N-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IPO7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the IPO7 ipo7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IPO7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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