Western Blot (WB)
(Western Blot analysis of Hela cell and Human testis tissue, A549, Jurkat and K562 cell using IPO4 Polyclonal Antibody at dilution of 1:550)
Rabbit IPO4 Polyclonal Antibody | anti-IPO4 antibody
IPO4 Polyclonal Antibody
IHC: 1:50-1:200
Western Blot (WB)
(Western Blot analysis of Hela cell and Human testis tissue, A549, Jurkat and K562 cell using IPO4 Polyclonal Antibody at dilution of 1:550)
Western Blot (WB)
(Western Blot analysis of Hela cell and Human testis tissue, A549, Jurkat and K562 cell using IPO4 Polyclonal Antibody at dilution of 1:550)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer using IPO4 Polyclonal Antibody at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer using IPO4 Polyclonal Antibody at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using IPO4 Polyclonal Antibody at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer using IPO4 Polyclonal Antibody at dilution of 1:50)
NCBI and Uniprot Product Information
Uniprot Description
IPO4: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Karyopherin; Nuclear import
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: protein complex; membrane; cytoplasm; nuclear chromatin; nuclear pore
Molecular Function: protein binding; Ran GTPase binding
Biological Process: intracellular protein transport; protein transport; DNA replication-independent nucleosome assembly; DNA replication-dependent nucleosome assembly
Research Articles on IPO4
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Product Notes
The IPO4 ipo4 (Catalog #AAA2527082) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IPO4 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IPO4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the IPO4 ipo4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IPO4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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