Knockout Validation
(Knockout Validation: Lane 1: Wild-type MCF7 cell lysate; Lane 2: IRF6 knockout MCF7 cell lysate; Predicted MW: 53,42kd Observed MW: 53kd Primary Ab: 2ug/ml Rabbit Anti-Human IRF6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Interferon Regulatory Factor 6 (IRF6) Polyclonal Antibody | anti-IRF6 antibody
HRP-Linked Polyclonal Antibody to Interferon Regulatory Factor 6 (IRF6)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type MCF7 cell lysate; Lane 2: IRF6 knockout MCF7 cell lysate; Predicted MW: 53,42kd Observed MW: 53kd Primary Ab: 2ug/ml Rabbit Anti-Human IRF6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type MCF7 cell lysate; Lane 2: IRF6 knockout MCF7 cell lysate; Predicted MW: 53,42kd Observed MW: 53kd Primary Ab: 2ug/ml Rabbit Anti-Human IRF6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Uniprot Description
IRF6: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: cytoplasm; cytosol
Molecular Function: DNA binding; protein binding; transcription factor activity
Biological Process: cell cycle arrest; negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent
Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1
Research Articles on IRF6
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Product Notes
The IRF6 irf6 (Catalog #AAA2061044) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HRP-Linked Polyclonal Antibody to Interferon Regulatory Factor 6 (IRF6) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Interferon Regulatory Factor 6 (IRF6) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the IRF6 irf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interferon Regulatory Factor 6 (IRF6), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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