Western Blot (WB)
(Anti- MUM1 antibody, MBS177517, Western blottingAll lanes: Anti MUM1 (MBS177517) at 0.5ug/mlWB: Recombinant Human MUM1 Protein 0.5ngPredicted bind size: 38KDObserved bind size: 38KD )
Rabbit Interferon regulatory factor 4 Polyclonal Antibody | anti-IRF4 antibody
Anti-MUM1 Antibody
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human
Western Blot (WB)
(Anti- MUM1 antibody, MBS177517, Western blottingAll lanes: Anti MUM1 (MBS177517) at 0.5ug/mlWB: Recombinant Human MUM1 Protein 0.5ngPredicted bind size: 38KDObserved bind size: 38KD )
Western Blot (WB)
(Anti- MUM1 antibody, MBS177517, Western blottingAll lanes: Anti MUM1 (MBS177517) at 0.5ug/mlWB: Recombinant Human MUM1 Protein 0.5ngPredicted bind size: 38KDObserved bind size: 38KD )
Western Blot (WB)
(Anti- MUM1 antibody, MBS177517, Western blottingAll lanes: Anti MUM1 (MBS177517) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugPredicted bind size: 51KDObserved bind size: 40KD )
Western Blot (WB)
(Anti- MUM1 antibody, MBS177517, Western blottingAll lanes: Anti MUM1 (MBS177517) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: JURKAT Whole Cell Lysate at 40ugPredicted bind size: 51KDObserved bind size: 40KD )
Immunohistochemistry (IHC)
(Anti- MUM1 antibody, MBS177517, IHC(P)IHC(P): Human Tonsil Tissue )
Immunohistochemistry (IHC)
(Anti- MUM1 antibody, MBS177517, IHC(P)IHC(P): Human Tonsil Tissue )
Background: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Uniprot Description
IRF4: Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Interacts with SPIB and DEF6. Not induced by interferons. Lymphoid cells. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p25-p23
Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; sequence-specific DNA binding; protein-lysine N-methyltransferase activity; transcription factor binding; transcription factor activity
Biological Process: T cell activation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; regulation of T-helper cell differentiation; myeloid dendritic cell differentiation; defense response to protozoan; peptidyl-lysine methylation; positive regulation of interleukin-4 biosynthetic process; positive regulation of interleukin-10 biosynthetic process; positive regulation of interleukin-13 biosynthetic process; negative regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA binding
Disease: Skin/hair/eye Pigmentation, Variation In, 8
Research Articles on IRF4
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Product Notes
The IRF4 irf4 (Catalog #AAA177517) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-MUM1 Antibody reacts with Human. No cross reactivity with other proteins. and may cross-react with other species as described in the data sheet. AAA Biotech's Interferon regulatory factor 4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC-P). Western Blot: Concentration: 0.1-0.5mug/ml; Tested Species: Human Immunohistochemistry (Paraffin-embedded Section): Concentration: 0.5-1mug/ml; Tested Species: Human. Researchers should empirically determine the suitability of the IRF4 irf4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Interferon regulatory factor 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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