Knockout Validation
(Knockout Validation: Lane 1: Wild-type A549 cell lysate; Lane 2: ITGaV knockout A549 cell lysate; Predicted MW: 116kDa Observed MW: 130kDa Primary Ab: 4ug/ml Rabbit Anti-Human ITGaV Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Integrin Alpha V (ITGaV) Polyclonal Antibody | anti-ITGaV antibody
Biotin-Linked Polyclonal Antibody to Integrin Alpha V (ITGaV)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type A549 cell lysate; Lane 2: ITGaV knockout A549 cell lysate; Predicted MW: 116kDa Observed MW: 130kDa Primary Ab: 4ug/ml Rabbit Anti-Human ITGaV Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type A549 cell lysate; Lane 2: ITGaV knockout A549 cell lysate; Predicted MW: 116kDa Observed MW: 130kDa Primary Ab: 4ug/ml Rabbit Anti-Human ITGaV Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Uniprot Description
ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q32.1
Cellular Component: cell surface; cytosol; external side of plasma membrane; filopodium membrane; focal adhesion; integral component of plasma membrane; integrin complex; membrane; microvillus membrane; phagocytic vesicle; plasma membrane
Molecular Function: C-X3-C chemokine binding; coreceptor activity; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; insulin-like growth factor I binding; metal ion binding; opsonin binding; peptide binding; protease binding; protein binding; protein kinase C binding; receptor binding; transforming growth factor beta binding; viral receptor activity; voltage-gated calcium channel activity
Biological Process: angiogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic cell clearance; cell adhesion; cell adhesion mediated by integrin; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; elevation of cytosolic calcium ion concentration; entry of symbiont into host cell by promotion of host phagocytosis; entry of virus into host cell; extracellular matrix organization; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; neutrophil degranulation; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of MAPK cascade; positive regulation of osteoblast proliferation; regulation of phagocytosis; vascular endothelial growth factor receptor signaling pathway; vasculogenesis
Research Articles on ITGaV
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Product Notes
The ITGaV itgav (Catalog #AAA2093093) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Integrin Alpha V (ITGaV) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Integrin Alpha V (ITGaV) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the ITGaV itgav for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Integrin Alpha V (ITGaV), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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