Rabbit Integrin alpha 1 Polyclonal Antibody | anti-ITGA1 antibody

Anti-Integrin alpha 1 antibody

Cat. Num. AAA177089

• Gene Names: ITGA1; VLA1; CD49a
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: Integrin alpha 1; Polyclonal Antibody; Anti-Integrin alpha 1 antibody; Integrin alpha-1; integrin; alpha 1; CD 49a antibody; CD49 antigen-like family member A antibody; CD49a antibody; CD49a antigen antibody; Integrin alpha-1 antibody; ITA1_HUMAN antibody; Itga 1 antibody; ITGA1 antibody; Laminin and collagen receptor antibody; Very late activation protein 1 antibody; VLA 1 antibody; VLA-1 antibody; VLA1 antibody; anti-ITGA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 1179

• Applicable Applications for anti-ITGA1 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1 (1121-1134aa SNQKRELAIQISKD), different from the related mouse and rat sequences by one amino acid.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-Integrin alpha 1 antibody, MBS177089, IHC(P)IHC(P): Human Lung Cancer Tissue )

Immunohistochemistry (IHC)

(Anti-Integrin alpha 1 antibody, MBS177089, IHC(P)IHC(P): Human Intestinal Cancer Tissue )

Immunohistochemistry (IHC)

(Anti-Integrin alpha 1 antibody, MBS177089, IHC(P)IHC(P): Rat Intestine Tissue )

Western Blot (WB)

(Anti-Integrin alpha 1 antibody, MBS177089,Western blottingAll lanes: Anti ITGA1 (MBS177089) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: HELA Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugPredicted bind size: 131KDObserved bind size: 131KD )

Related Product Information for anti-ITGA1 antibody

Description: Rabbit IgG polyclonal antibody for Integrin alpha-1(ITGA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: Integrin alpha 1(ITGA1) chain associates with the beta 1(ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

NCBI and Uniprot Product Information

• NCBI GI #: 124056463
• NCBI GeneID: 3672
• UniProt Accession #: P56199; B2RNU0
• Molecular Weight: 130,848 Da
• NCBI Official Full Name: Integrin alpha-1
• NCBI Official Synonym Full Names: integrin, alpha 1
• NCBI Official Symbol: ITGA1
• NCBI Official Synonym Symbols: VLA1; CD49a
• NCBI Protein Information: integrin alpha-1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A
• UniProt Protein Name: Integrin alpha-1
• Protein Family: Integrin
• UniProt Gene Name: ITGA1
• UniProt Entry Name: ITA1_HUMAN

NCBI Description

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

Uniprot Description

ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: neuron projection; focal adhesion; cell surface; membrane; acrosome; plasma membrane; perikaryon; integrin complex; lipid raft; external side of plasma membrane

Molecular Function: collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding

Biological Process: positive regulation of phosphoprotein phosphatase activity; negative regulation of epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; axon guidance; neutrophil chemotaxis; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation