Western Blot (WB)
(Western Blot: Sample: Mouse Brain Tissue.)
Rabbit anti-Mouse Insulin Receptor Substrate 1 Polyclonal Antibody | anti-IRS1 antibody
Polyclonal Antibody to Insulin Receptor Substrate 1 (IRS1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEFELRR QAC- PRKV DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQSSL HPPEPKSPGE YVNIEFGSGQ PGYLAGPATS RSSPSVRCPP QLHPAPREET GSEEYMNMDL GPGRRATWQE SGGVELGRIG PAPPGSATVC RPTRSVPNSR GDYMTMQIGC PRQSYVDTSP VAPVSYADMR TGIAAEKASL PRPTGAAPPP SSTASSSASV TPQGATAEQA THSSLLGGPQ GPGGMSAFTR VNLSPNHNQS
Immunohistochemistry: 5-20ug/mL;1:50-200
Immunocytochemistry: 5-20ug/mL;1:50-200
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Mouse Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Mouse Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant IRS1, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant IRS1, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Mouse Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P. Samples: Mouse Tissue))
NCBI and Uniprot Product Information
Uniprot Description
IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1 C5|1 42.0 cM
Cellular Component: caveola; cytoplasm; cytosol; insulin receptor complex; intracellular membrane-bound organelle; nucleus; plasma membrane
Molecular Function: insulin receptor binding; insulin-like growth factor receptor binding; phosphoinositide 3-kinase binding; phosphotyrosine binding; protein binding; protein domain specific binding; protein kinase binding; protein kinase C binding; SH2 domain binding; signal transducer activity; transmembrane receptor protein tyrosine kinase adaptor protein activity
Biological Process: cellular response to angiotensin; cellular response to insulin stimulus; insulin receptor signaling pathway; insulin secretion; insulin-like growth factor receptor signaling pathway; lipid catabolic process; mammary gland development; negative regulation of insulin receptor signaling pathway; negative regulation of insulin secretion; negative regulation of somatostatin secretion; phosphoinositide 3-kinase cascade; positive regulation of cell migration; positive regulation of fatty acid beta-oxidation; positive regulation of glucagon secretion; positive regulation of glucose import; positive regulation of glucose import in response to insulin stimulus; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of mesenchymal cell proliferation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phosphorylation; protein heterooligomerization; protein kinase B signaling; protein localization to nucleus; regulation of gene expression; response to caffeine; response to insulin stimulus; response to peptide hormone; signal transduction
Research Articles on IRS1
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Product Notes
The IRS1 irs1 (Catalog #AAA2026844) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Insulin Receptor Substrate 1 (IRS1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Insulin Receptor Substrate 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL;1:500-2000 Immunohistochemistry: 5-20ug/mL;1:50-200 Immunocytochemistry: 5-20ug/mL;1:50-200 Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the IRS1 irs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEFELRR QAC- PRKV DTAAQTNSRL ARPTRLSLGD PKASTLPRVR EQQQQQQSSL HPPEPKSPGE YVNIEFGSGQ PGYLAGPATS RSSPSVRCPP QLHPAPREET GSEEYMNMDL GPGRRATWQE SGGVELGRIG PAPPGSATVC RPTRSVPNSR GDYMTMQIGC PRQSYVDTSP VAPVSYADMR TGIAAEKASL PRPTGAAPPP SSTASSSASV TPQGATAEQA THSSLLGGPQ GPGGMSAFTR VNLSPNHNQS. It is sometimes possible for the material contained within the vial of "Insulin Receptor Substrate 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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