Rabbit anti-Human, Mouse Insulin Receptor R Polyclonal Antibody | anti-INSRR antibody
Insulin Receptor R (N-Term) Rabbit pAb
IHC: 1:10-50
NCBI and Uniprot Product Information
Uniprot Description
IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; InsR family
Chromosomal Location of Human Ortholog: 1q21-q23
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on INSRR
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Product Notes
The INSRR insrr (Catalog #AAA8558329) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Insulin Receptor R (N-Term) Rabbit pAb reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Insulin Receptor R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:2000 IHC: 1:10-50. Researchers should empirically determine the suitability of the INSRR insrr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Insulin Receptor R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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