Rabbit anti-Human, Mouse INPP5F Polyclonal Antibody | anti-INPP5F antibody
INPP5F Antibody
Gene Names
INPP5F; SAC2; hSAC2; MSTP007; MSTPO47
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
INPP5F; Polyclonal Antibody; INPP5F Antibody; cI-27; hSAC2; Inositol polyphosphate 5 phosphatase F; KIAA0966; MSTP007; MSTP047; Phosphatidylinositide phosphatase SAC2; Sac domain containing inositol phosphatase 2; Sac domain-containing phosphoinositide 5-phosphatase 2; SAC2; anti-INPP5F antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
INPP5F Antibody detects endogenous levels of INPP5F.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-INPP5F antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human INPP5F.
Conjugation
Unconjugated
Subunit Structure
Homodimer. Interacts with OCRL and RAB5A. Interacts with INPP5B and INPP4A. Interacts with STAT3; the interaction is independent of STAT3 'TYR-705' phosphorylation status.
Tissue Specificity
Ubiquitous. Highly expressed in brain.
Function
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4, 5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4, 5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).
Note
Also found on macropinosomes.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-INPP5F antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,800 Da
NCBI Official Full Name
phosphatidylinositide phosphatase SAC2 isoform 2
NCBI Official Synonym Full Names
inositol polyphosphate-5-phosphatase F
NCBI Official Symbol
INPP5F
NCBI Official Synonym Symbols
SAC2; hSAC2; MSTP007; MSTPO47
NCBI Protein Information
phosphatidylinositide phosphatase SAC2; Sac domain-containing inositol phosphatase 2; sac domain-containing phosphoinositide 5-phosphatase 2
UniProt Protein Name
Phosphatidylinositide phosphatase SAC2
Protein Family
UniProt Gene Name
INPP5F
UniProt Synonym Gene Names
KIAA0966; SAC2; hSAC2
UniProt Entry Name
SAC2_HUMAN
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Product Notes
The INPP5F inpp5f (Catalog #AAA9630112) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INPP5F Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's INPP5F can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the INPP5F inpp5f for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INPP5F, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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