Rabbit anti-Human Inositol 1,4,5-trisphosphate 3-kinase A Polyclonal Antibody | anti-IP3KA antibody

Inositol 1,4,5-trisphosphate 3-kinase A, NT (Inositol-trisphosphate 3-kinase A, InsP 3-kinase A, IP3 3-kinase A, IP3K A, IP3KA, IP3-3KA, ITPKA) (APC)

Cat. Num. AAA6481765

• Gene Names: ITPKA; IP3KA; IP3-3KA
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein G Affinity Chromatography.
• Synonyms: Inositol 1; 4; 5-trisphosphate 3-kinase A; Polyclonal Antibody; NT (Inositol-trisphosphate 3-kinase A; InsP 3-kinase A; IP3 3-kinase A; IP3K A; IP3KA; IP3-3KA; ITPKA) (APC); EC=2.7.1.127; anti-IP3KA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ITPKA.
• Purity/Purification: Purified by Protein G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-IP3KA antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the N-terminal region of human ITPKA (KLH).
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-ITPKA Antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). ITPKA(arrow) was detected using the purified Pab.)

Product Categories/Family for anti-IP3KA antibody

Antibodies; Protein Kinases

References

1. Gonzalez, B., et al., Mol. Cell 15(5):689-701 (2004). 2. Mishra, J., et al., Biophys. J. 83(3):1298-1316 (2002). 3. Schell, M.J., et al., J. Biol. Chem. 276(40):37537-37546 (2001). 4. Communi, D., et al., EMBO J. 16(8):1943-1952 (1997). 5. Woodring, P.J., et al., J. Biol. Chem. 272(48):30447-30454 (1997).

NCBI and Uniprot Product Information

• NCBI GI #: 4504789
• NCBI GeneID: 3706
• NCBI Accession #: NP_002211
• NCBI GenBank Nucleotide #: NM_002220.2
• UniProt Accession #: P23677; Q8TAN3
• Molecular Weight: 51,009 Da
• NCBI Official Full Name: inositol-trisphosphate 3-kinase A
• NCBI Official Synonym Full Names: inositol-trisphosphate 3-kinase A
• NCBI Official Symbol: ITPKA
• NCBI Official Synonym Symbols: IP3KA; IP3-3KA
• NCBI Protein Information: inositol-trisphosphate 3-kinase A
• UniProt Protein Name: Inositol-trisphosphate 3-kinase A
• UniProt Gene Name: ITPKA
• UniProt Synonym Gene Names: IP3 3-kinase A; IP3K A
• UniProt Entry Name: IP3KA_HUMAN

NCBI Description

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Uniprot Description

ITPKA: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Protein type: Kinase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: dendritic spine; cytosol

Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; Rac GTPase binding; inositol trisphosphate 3-kinase activity; ATP binding

Biological Process: inositol phosphate metabolic process; inositol metabolic process; regulation of synaptic plasticity; signal transduction; actin cytoskeleton organization and biogenesis; protein amino acid phosphorylation