Rabbit anti-Human, Mouse INIP Polyclonal Antibody | anti-INIP antibody
INIP Antibody
Gene Names
INIP; MISE; SOSSC; SSBIP1; C9orf80; HSPC043; hSSBIP1
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
INIP; Polyclonal Antibody; INIP Antibody; Chromosome 9 open reading frame 80; hSSBIP1; MISE; RP11-276E15.2; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; Single-stranded DNA-binding protein-interacting protein 1; SOSS C; SOSS complex subunit C; SOSS-C; SOSSC; SOSSC_HUMAN; SSB-interacting protein 1; Ssbip1; anti-INIP antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
INIP Antibody detects endogenous levels of INIP.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-INIP antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human INIP.
Conjugation
Unconjugated
Similarity
Belongs to the SOSS-C family.
Subunit Structure
Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is direct.
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Note
Localizes to nuclear foci following DNA damage.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
4,904 Da
NCBI Official Full Name
SOSS complex subunit C
NCBI Official Synonym Full Names
INTS3 and NABP interacting protein
NCBI Official Symbol
INIP
NCBI Official Synonym Symbols
MISE; SOSSC; SSBIP1; C9orf80; HSPC043; hSSBIP1
NCBI Protein Information
SOSS complex subunit C
UniProt Protein Name
SOSS complex subunit C
Protein Family
UniProt Gene Name
INIP
UniProt Synonym Gene Names
C9orf80; SSBIP1; SOSS-C; SSB-interacting protein 1; hSSBIP1
UniProt Entry Name
SOSSC_HUMAN
NCBI Description
SOSSC is a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
Uniprot Description
INIP: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-C family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 9q32
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: response to ionizing radiation; DNA repair; response to DNA damage stimulus
Research Articles on INIP
1. hSSBIP1 forms complexes with INTS3/hSSB1 and INTS3/hSSB2 and participates in the DNA damage response
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Product Notes
The INIP inip (Catalog #AAA9630403) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INIP Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's INIP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the INIP inip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INIP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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