Rabbit anti-Human Inhibin beta-C Polyclonal Antibody | anti-AGER antibody

Inhibin beta-C (V129) Polyclonal Antibody

Cat. Num. AAA3003752

• Gene Names: INHBC; IHBC
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Inhibin beta-C; Polyclonal Antibody; Inhibin beta-C (V129) Polyclonal Antibody; Inhibin beta C chain; Activin beta-C chain; INHBC; anti-AGER antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Inhibin beta-C (V129) polyclonal antibody detects endogenous levels of Inhibin beta-C protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 352

• Applicable Applications for anti-AGER antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human Inhibin beta-C.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Inhibin beta-C (V129) pAb in paraffin-embedded human liver carcinoma tissue at 1:50.showing strong cytoplasmic staining. Negative control (the right) Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.)

Related Product Information for anti-AGER antibody

Inhibins and activins are involved in regulating a number of functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth depending on their subunit composition. Activins oppose the funtions of inhibins. Inhibins are predominantly expressed in liver, uterus and ovary tissue, but also in benign prostatic hyperplasia. Inhibin A, a dimer of alpha and beta-A, and inhibin B, a dimer of alpha and beta-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin beta-C forms a homodimer and its expression is predominant in adult liver and in benign prostatic hyperplasia.

NCBI and Uniprot Product Information

• NCBI GI #: 5031795
• NCBI GeneID: 3626
• NCBI Accession #: NP_005529.1
• NCBI GenBank Nucleotide #: NP_005529.1
• UniProt Accession #: P55103
• Molecular Weight: ~ 30kDa
• NCBI Official Full Name: inhibin beta C chain preproprotein
• NCBI Official Synonym Full Names: inhibin subunit beta C
• NCBI Official Symbol: INHBC
• NCBI Official Synonym Symbols: IHBC
• NCBI Protein Information: inhibin beta C chain
• UniProt Protein Name: Inhibin beta C chain
• Protein Family: Advanced glycosylation end product-specific receptor
• UniProt Gene Name: INHBC
• UniProt Entry Name: INHBC_HUMAN

NCBI Description

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of homodimeric and heterodimeric activin complexes. The heterodimeric complex may function in the inhibition of activin A signaling. Transgenic mice overexpressing this gene exhibit defects in testis, liver and prostate. [provided by RefSeq, Aug 2016]

Uniprot Description

INHBC: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: extracellular space; extracellular region

Molecular Function: growth factor activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: regulation of apoptosis; regulation of MAPKKK cascade; cell development; growth