Rabbit ING3 Polyclonal Antibody | anti-ING3 antibody

ING3-specific Rabbit Polyclonal

Cat. Num. AAA7600545

• Gene Names: ING3; Eaf4; ING2; MEAF4; p47ING3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ING3; Polyclonal Antibody; ING3-specific Rabbit Polyclonal; anti-ING3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 418

• Applicable Applications for anti-ING3 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Inhibitor of growth family, member 3
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(human kidney tissue were subjected to SDS PAGE followed by western blot with MBS7600545 (ING3-specific antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 38201655
• NCBI GeneID: 54556
• NCBI Accession #: NP_061944.2
• NCBI GenBank Nucleotide #: NM_019071.2
• Molecular Weight: 11,449 Da
• NCBI Official Full Name: inhibitor of growth protein 3 isoform 1
• NCBI Official Synonym Full Names: inhibitor of growth family member 3
• NCBI Official Symbol: ING3
• NCBI Official Synonym Symbols: Eaf4; ING2; MEAF4; p47ING3
• NCBI Protein Information: inhibitor of growth protein 3
• UniProt Protein Name: Inhibitor of growth protein 3
• Protein Family: Inhibitor of growth protein
• UniProt Gene Name: ING3
• UniProt Entry Name: ING3_HUMAN

NCBI Description

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

ING3: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Defects in ING3 may be a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: cytoplasm; NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus

Molecular Function: histone acetyltransferase activity; methylated histone residue binding; zinc ion binding

Biological Process: positive regulation of apoptosis; regulation of growth; regulation of transcription, DNA-dependent; transcription, DNA-dependent