Rabbit anti-Human, Mouse ING1 Polyclonal Antibody | anti-ING1 antibody

ING1-specific Rabbit Polyclonal

Cat. Num. AAA7600542

• Gene Names: ING1; p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ING1; Polyclonal Antibody; ING1-specific Rabbit Polyclonal; anti-ING1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 235

• Applicable Applications for anti-ING1 antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: Inhibitor of growth family, member 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(human heart tissue were subjected to SDS PAGE followed by western blot with MBS7600542 (ING1-specific antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 7158369
• NCBI GeneID: 3621
• Molecular Weight: 29,572 Da
• NCBI Official Full Name: ING1 tumor suppressor, variant C
• NCBI Official Synonym Full Names: inhibitor of growth family member 1
• NCBI Official Symbol: ING1
• NCBI Official Synonym Symbols: p33; p47; p33ING1; p24ING1c; p33ING1b; p47ING1a
• NCBI Protein Information: inhibitor of growth protein 1
• UniProt Protein Name: Inhibitor of growth protein 1
• Protein Family: Inhibitor of growth protein
• UniProt Gene Name: ING1
• UniProt Entry Name: ING1_HUMAN

NCBI Description

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

ING1: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene. Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: methylated histone residue binding; protein binding; zinc ion binding

Biological Process: cell cycle; chromatin modification; negative regulation of cell growth; negative regulation of cell proliferation

Disease: Squamous Cell Carcinoma, Head And Neck