Rabbit anti-Mouse IL23 P19  Polyclonal Antibody | anti-IL23A antibody

Anti-IL23 P19  antibody

Cat. Num. AAA175539

• Gene Names: Il23a; p19; IL-23
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: IL23 P19 ; Polyclonal Antibody; Anti-IL23 P19 antibody; Interleukin-23 subunit alpha(IL-23 subunit alpha/IL-23-A); interleukin 23; alpha subunit p19; alpha subunit P19 antibody; IL-23 subunit alpha antibody; IL-23-A antibody; IL-23p19 antibody; IL23 antibody; IL23 P 19 antibody; IL23A antibody; IL23A_HUMAN antibody; IL23P19 antibody; interleukin 23 alpha subunit p19 antibody; interleukin 23 P19 subunit antibody; Interleukin-23 subunit alpha antibody; Interleukin-23 subunit p19 antibody; JKA3 induced upon T cell activation antibody; MGC79388 antibody; P19 antibody; SGRF antibody; anti-IL23A antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 196

• Applicable Applications for anti-IL23A antibody: Western Blot (WB)
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse IL23 P19 (29-48aa DWAQCQQLSRNLCMLAWNAH), different from the related rat sequence by two amino acids.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Testing Data

(All lanes: Anti-IL23 P19  antibody, MBS175539 Lane 1: Recombinant Mouse IL-23 Protein 10ngLane 2: Recombinant Mouse IL-23 Protein 5ngLane 3: Recombinant Mouse IL-23 Protein 2.5ng)

Related Product Information for anti-IL23A antibody

Description: Rabbit IgG polyclonal antibody for Interleukin-23 subunit alpha(IL23A) detection. Tested with WB in Mouse.
Background: IL-23, Interleukin-23, also known as Interleukin-23 subunit alphainin(IL23A), is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19(the IL-23 alpha subunit). The International Radiation Hybrid Mapping Consortium mapped the IL-23 gene to chromosome 12. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration.

NCBI and Uniprot Product Information

• NCBI GI #: 81881842
• NCBI GeneID: 83430
• UniProt Accession #: Q9EQ14
• Molecular Weight: 22,071 Da
• NCBI Official Full Name: Interleukin-23 subunit alpha
• NCBI Official Synonym Full Names: interleukin 23, alpha subunit p19
• NCBI Official Symbol: Il23a
• NCBI Official Synonym Symbols: p19; IL-23
• NCBI Protein Information: interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin-23 subunit p19
• UniProt Protein Name: Interleukin-23 subunit alpha
• Protein Family: Interleukin
• UniProt Gene Name: Il23a
• UniProt Synonym Gene Names: IL-23 subunit alpha; IL-23-A; IL-23p19
• UniProt Entry Name: IL23A_MOUSE

Uniprot Description

IL23A: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily.

Protein type: Secreted; Cytokine; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; cytokine activity; interleukin-23 receptor binding

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of T-helper 1 type immune response; negative regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of T cell mediated cytotoxicity; positive regulation of osteoclast differentiation; tissue remodeling; positive regulation of NK T cell proliferation; positive regulation of tyrosine phosphorylation of Stat4 protein; defense response to Gram-negative bacterium; positive regulation of activated T cell proliferation; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; T cell proliferation; positive regulation of T cell proliferation; inflammatory response; defense response to virus; positive regulation of memory T cell differentiation; positive regulation of interleukin-17 production; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; immune system process; positive regulation of tumor necrosis factor production; regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; innate immune response; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of defense response to virus by host