Rabbit anti-Human, Mouse IL20 Polyclonal Antibody | anti-IL20 antibody

IL20 Polyclonal Antibody

Cat. Num. AAA3011634

• Gene Names: IL20; IL-20; IL10D; ZCYTO10
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IL20; Polyclonal Antibody; IL20 Polyclonal Antibody; Interleukin-20; IL-20; Cytokine Zcyto10; ZCYTO10; UNQ852; PRO1801; anti-IL20 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IL20 polyclonal antibody detects endogenous levels of IL20 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 176

• Applicable Applications for anti-IL20 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human IL20.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using IL20 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse lung using IL20 antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using IL20 antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-IL20 antibody

IL-14 (high-molecular-weight B-cell growth factor or HMW-BCGF) is a 53kDa protein that plays a significant role in the rapid proliferation of aggressive B-cell type non-Hodgkin's lymphoma. IL-19 and IL-20 are IL-10-related cytokines. IL-19 is involved in melanoma differentiation, and IL-20 plays an essential role in epidermal function and psoriasis. Like other interleukin molecules, IL-21 is a small secreted molecule, and it has potent effects on lymphoid cells. IL-21 is most closely related to IL-2 and IL-15 and has a role in the proliferation and maturation of natural killer cell populations from bone marrow, in the proliferation of mature B-cell populations co-stimulated with anti-CD40, and in the proliferation of T cells co-stimulated with anti-CD3.

NCBI and Uniprot Product Information

• NCBI GI #: 31083166
• NCBI GeneID: 50604
• NCBI Accession #: NP_061194.2
• NCBI GenBank Nucleotide #: NP_061194.2
• UniProt Accession #: Q9NYY1
• Molecular Weight: ~ 20kDa
• NCBI Official Full Name: interleukin-20
• NCBI Official Synonym Full Names: interleukin 20
• NCBI Official Symbol: IL20
• NCBI Official Synonym Symbols: IL-20; IL10D; ZCYTO10
• NCBI Protein Information: interleukin-20
• UniProt Protein Name: Interleukin-20
• Protein Family: Interleukin
• UniProt Gene Name: IL20
• UniProt Synonym Gene Names: ZCYTO10; IL-20
• UniProt Entry Name: IL20_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

Uniprot Description

IL20: Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. Belongs to the IL-10 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; extracellular region

Molecular Function: interleukin-20 receptor binding; interleukin-22 receptor binding; cytokine activity

Biological Process: positive regulation of osteoclast differentiation; positive regulation of epidermal cell differentiation; regulation of inflammatory response; positive regulation of JAK-STAT cascade; immune response; inflammatory response; positive regulation of keratinocyte differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein