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Western Blot (WB)
Rabbit anti-Human, Mouse IL2 Polyclonal Antibody | anti-IL2 antibody
Anti-IL2 Antibody
Gene Names
IL2; IL-2; TCGF; POIL2
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry
Purity
Affinity Purification
Synonyms
IL2; Polyclonal Antibody; Anti-IL2 Antibody; anti-IL2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Western blot analysis of CTLL-2 cell lysate using IL-2 antibody. Immunohistochemistry of paraffin-embedded mouse spleen using IL-2 antibody at dilution of 1:100 (200x lens). Immunohistochemistry of paraffin-embedded mouse spleen using IL-2 antibody at dilution of 1:100 (400x lens). Immunohistochemistry of paraffin-embedded human liver cancer using IL-2 antibody at dilution of 1:100 (200x lens). Immunohistochemistry of paraffin-embedded human esophageal cancer using IL-2 antibody at dilution of 1:100 (200x lens).
Purity/Purification
Affinity Purification
Form/Format
Liquid
Concentration
1mg/ml (varies by lot)
Sequence Length
154
Applicable Applications for anti-IL2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes
WB: 1:500 - 1:2000
IHC: 1:50- 1:200
ICC: 1:50- 1:200
IHC: 1:50- 1:200
ICC: 1:50- 1:200
Immunogen
Recombinant protein of human IL2
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Western Blot (WB)
Western Blot (WB)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Related Product Information for anti-IL2 antibody
IL-2 is a T cell stimulatory cytokine best known for inducing T cell proliferation and NK cell proliferation and activation (1, 2). IL-2 also promotes peripheral development of Treg cells (4,5). Conversely, IL-2 is involved in activation induced cell death (AICD) that is observed post T cell expansion by increasing levels of Fas on CD4+ T cells (3). The effects of IL-2 are mediated through a trimeric receptor complex consisting of IL-2R+/-, IL-2R2 and the common gamma chain, 3c (1, 2). IL-2 R+/- binds exclusively to IL-2 with low affinity and increases binding affinity of the whole receptor complex including IL-2R2 and 3c subunits. IL-2R2 is also used by IL-15 (1, 2). The common 3c is used by other cytokines including IL-4, IL-7, IL-9, IL-15, and IL-21 (1, 2). Binding of IL-2 initiates signaling cascades involving Jak1, Jak3, Stat5 and the PI3K/Akt pathways (1, 2).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
17,401 Da
NCBI Official Full Name
interleukin-2
NCBI Official Symbol
IL2
NCBI Official Synonym Symbols
IL-2; TCGF; POIL2
NCBI Protein Information
interleukin-2
UniProt Protein Name
Interleukin-2
Protein Family
UniProt Gene Name
IL2
UniProt Synonym Gene Names
IL-2; TCGF
Uniprot Description
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Research Articles on IL2
Similar Products
Product Notes
The IL2 il2 (Catalog #AAA419435) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-IL2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). WB: 1:500 - 1:2000 IHC: 1:50- 1:200 ICC: 1:50- 1:200. Researchers should empirically determine the suitability of the IL2 il2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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