Rabbit IL18RAP Polyclonal Antibody | anti-IL18RAP antibody
IL18RAP Antibody FITC
Gene Names
IL18RAP; ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
Reactivity
Human, RatPredicted: Mouse
Applications
ELISA, Immunoprecipitation, Western Blot
Purity
Immobilized antigen affinity chromatography
Synonyms
IL18RAP; Polyclonal Antibody; IL18RAP Antibody FITC; FITC-Conjugated Interleukin-18 receptor accessory protein Antibody; IL18RAP antibody; Accessory protein like antibody; AcPL antibody; CD218 antigen-like family member B antibody; CDw218b antibody; IL-18R-beta antibody; IL-18RAcP antibody; IL-18Rbeta antibody; IL-1R accessory protein-like antibody; IL-1R7 antibody; IL-1RAcPL antibody; IL18Rbeta antibody; Interleukin 18 receptor accessory protein antibody; Interleukin-1 receptor 7 antibody; Interleukin-18 receptor beta antibody; anti-IL18RAP antibody
Host
Rabbit
Reactivity
Human, Rat
Predicted: Mouse
Predicted: Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immobilized antigen affinity chromatography
Concentration
0.5 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
599
Applicable Applications for anti-IL18RAP antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
ELISA: 1:10,000
IP: 1:150
WB: 1:500
IP: 1:150
WB: 1:500
Immunogen
Synthetic peptide taken within amino acid region 500-550 on human Interleukin-18 receptor accessory protein.
Conjugation
FITC
Molecular Function
Receptor activity
Subcellular Location
Membrane; Single-pass type I membrane protein
Preparation and Storage
Store at -20 degree C for long term storage.
Related Product Information for anti-IL18RAP antibody
Overview: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.
Structure: Belongs to the interleukin-1 receptor family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain.
Expression: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.
Structure: Belongs to the interleukin-1 receptor family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain.
Expression: Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
14,660 Da
NCBI Official Full Name
interleukin-18 receptor accessory protein
NCBI Official Synonym Full Names
interleukin 18 receptor accessory protein
NCBI Official Symbol
IL18RAP
NCBI Official Synonym Symbols
ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta
NCBI Protein Information
interleukin-18 receptor accessory protein
UniProt Protein Name
Interleukin-18 receptor accessory protein
Protein Family
UniProt Gene Name
IL18RAP
UniProt Synonym Gene Names
IL-18R-beta; IL-18Rbeta
NCBI Description
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Uniprot Description
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Research Articles on IL18RAP
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Product Notes
The IL18RAP il18rap (Catalog #AAA5400451) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL18RAP Antibody FITC reacts with Human, Rat Predicted: Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL18RAP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). ELISA: 1:10,000 IP: 1:150 WB: 1:500. Researchers should empirically determine the suitability of the IL18RAP il18rap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL18RAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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