Rabbit anti-Human IL17RC Polyclonal Antibody | anti-IL17RC antibody

IL17RC, NT (IL17RC, Interleukin-17 receptor C, Interleukin-17 receptor homolog, Interleukin-17 receptor-like protein, ZcytoR14) (Biotin)

Cat. Num. AAA6309972

• Gene Names: IL17RC; CANDF9; IL17RL; IL17-RL
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IL17RC; Polyclonal Antibody; NT (IL17RC; Interleukin-17 receptor C; Interleukin-17 receptor homolog; Interleukin-17 receptor-like protein; ZcytoR14) (Biotin); ZcytoR14; anti-IL17RC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-IL17RC antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: IL17RC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-131 amino acids from the N-terminal region of human IL17RC.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(IL17RC Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the IL17RC antibody detected the IL17RC protein (arrow).)

Related Product Information for anti-IL17RC antibody

This gene encodes a single-pass transmembrane protein that shares limited similarity with the interleukin-17 receptor. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only three have been determined to date.

Product Categories/Family for anti-IL17RC antibody

Antibodies; Interleukin

References

Pickens, S.R., et al. J. Immunol. 184(6):3233-3241(2010). Wright, J.F., et al. J. Immunol. 181(4):2799-2805(2008). Zrioual, S., et al. J. Immunol. 180(1):655-663(2008). Kuestner, R.E., et al. J. Immunol. 179(8):5462-5473(2007). Haudenschild, D.R., et al. Prostate 66(12):1268-1274(2006).

NCBI and Uniprot Product Information

• NCBI GI #: 90669934
• NCBI GeneID: 84818
• NCBI Accession #: NP_116121.2
• NCBI GenBank Nucleotide #: NM_032732.5
• UniProt Accession #: Q8NAC3; Q6UVY3; Q6UWD4; Q8NFS1; Q9BR97; A8BWC1; A8BWC9; A8BWD5; E9PHG1; E9PHJ6
• Molecular Weight: 75,432 Da
• NCBI Official Full Name: interleukin-17 receptor C isoform 3
• NCBI Official Synonym Full Names: interleukin 17 receptor C
• NCBI Official Symbol: IL17RC
• NCBI Official Synonym Symbols: CANDF9; IL17RL; IL17-RL
• NCBI Protein Information: interleukin-17 receptor C
• UniProt Protein Name: Interleukin-17 receptor C
• Protein Family: Interleukin-17 receptor
• UniProt Gene Name: IL17RC
• UniProt Synonym Gene Names: IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL
• UniProt Entry Name: I17RC_HUMAN

NCBI Description

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Uniprot Description

IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1

Cellular Component: integral to plasma membrane

Molecular Function: interleukin-17 receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway

Disease: Candidiasis, Familial, 9