Rabbit IL-9R Polyclonal Antibody | anti-IL-9R antibody

IL-9R (L514) Polyclonal Antibody

Cat. Num. AAA3001488

• Gene Names: IL9R; CD129; IL-9R
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IL-9R; Polyclonal Antibody; IL-9R (L514) Polyclonal Antibody; Interleukin-9 receptor; IL-9 receptor; CD129; IL9R; anti-IL-9R antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IL-9R (L514) polyclonal antibody detects endogenous levels of IL-9R protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 521

• Applicable Applications for anti-IL-9R antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 480-530 of Human IL-9R.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of IL-9R (L514) polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:A549 whole cell lysateLane3:H9C2 whole cell lysate)

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of IL-9R (L514) pAb in paraffin-embedded human liver carcinoma tissue at 1:100.)

Related Product Information for anti-IL-9R antibody

Human Interleukin 9 (IL9) was first identified based on its proliferative activity on a human myeloid leukemic cell line. Human IL9 stimulates the proliferation of the human megakaryocytic leukemic cell line M07e. Human IL9 supports erythroid colony formation and synergizes with IL4 in the production of IgE and IgG. The interleukin 9 receptor is a member of the hematopoietin receptor superfamily. The cDNAs encoding mouse and human IL9 receptors have been isolated. The deduced mouse and human transmembrane proteins, sharing 53% amino acid sequence identity, contain 468 and 533 amino acid residues, respectively. A number of isoforms of IL9R, including a putative soluble form, have also been identified. The IL9 receptor is expressed in a variety of hematopoietic cells including T cells, neutrophils, mast cells, and macrophages.

NCBI and Uniprot Product Information

• NCBI GI #: 29171682
• NCBI GeneID: 3581
• NCBI Accession #: NP_002177.2
• NCBI GenBank Nucleotide #: NP_002177.2
• UniProt Accession #: Q01113
• Molecular Weight: ~ 70kDa
• NCBI Official Full Name: interleukin-9 receptor isoform 1
• NCBI Official Synonym Full Names: interleukin 9 receptor
• NCBI Official Symbol: IL9R
• NCBI Official Synonym Symbols: CD129; IL-9R
• NCBI Protein Information: interleukin-9 receptor
• UniProt Protein Name: Interleukin-9 receptor
• UniProt Gene Name: IL9R
• UniProt Synonym Gene Names: IL-9 receptor; IL-9R
• UniProt Entry Name: IL9R_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

IL9R: This is a receptor for interleukin-9. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: interleukin-9 binding; interleukin-9 receptor activity

Biological Process: cell proliferation; signal transduction; positive regulation of cell growth