Rabbit anti-Human IL-6Ralpha Polyclonal Antibody | anti-IL-6Ralpha antibody

IL-6Ralpha Rabbit pAb

Gene Names

IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1

Reactivity

Human

Applications

Western Blot, ELISA

Purity

Affinity Purified

Synonyms

IL-6Ralpha; Polyclonal Antibody; IL-6Ralpha Rabbit pAb; IL6R; Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126; anti-IL-6Ralpha antibody

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Cat. Num. AAA8540915 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Purity/Purification

Affinity Purified

Form/Format

Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.

Sequence Length

Applicable Applications for anti-IL-6Ralpha antibody

Western Blot (WB), ELISA (EIA)

Application Notes

WB: 1:500-1:2000
ELISA: 1:10000

Immunogen

Synthesized peptide derived from IL-6Ralpha. at AA range: INTERNAL

Cellular Localization

Cell Membrane, Membrane, Secreted

Preparation and Storage

Store at -20 degree C for 1 year.

NCBI and Uniprot Product Information

NCBI GI #

633863

NCBI GeneID

3570

UniProt Accession #

P08887

NCBI Official Full Name

Soluble interleukin-6 receptor, partial

NCBI Official Synonym Full Names

interleukin 6 receptor

NCBI Official Symbol

IL6R

NCBI Official Synonym Symbols

IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1

NCBI Protein Information

interleukin-6 receptor subunit alpha

UniProt Protein Name

Interleukin-6 receptor subunit alpha

UniProt Gene Name

IL6R

UniProt Synonym Gene Names

IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80

UniProt Entry Name

IL6RA_HUMAN

NCBI Description

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

Uniprot Description

IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; basolateral plasma membrane; apical plasma membrane; extracellular region; plasma membrane; interleukin-6 receptor complex

Molecular Function: protein binding; interleukin-6 binding; protein homodimerization activity; enzyme binding; interleukin-6 receptor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity

Biological Process: positive regulation of smooth muscle cell proliferation; negative regulation of collagen biosynthetic process; cytokine and chemokine mediated signaling pathway; neutrophil mediated immunity; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; defense response to Gram-negative bacterium; endocrine pancreas development; positive regulation of chemokine production; activation of NF-kappaB transcription factor; positive regulation of tyrosine phosphorylation of Stat3 protein; monocyte chemotaxis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; acute-phase response; negative regulation of interleukin-8 production; hepatic immune response

Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus

Research Articles on IL-6Ralpha

1. Elevated plasma interleukin 6 receptor is associated with poor response to sunitinib in metastatic clear cell renal cell carcinoma.

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Product Notes

The IL-6Ralpha il6r (Catalog #AAA8540915) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-6Ralpha Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-6Ralpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:500-1:2000 ELISA: 1:10000. Researchers should empirically determine the suitability of the IL-6Ralpha il6r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-6Ralpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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