Rabbit anti-Mouse, Rat IL-4R Polyclonal Antibody | anti-IL-4R antibody

IL-4R polyclonal antibody

Cat. Num. AAA3013857

• Gene Names: Il4r; Il4ra
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: IL-4R; Polyclonal Antibody; IL-4R polyclonal antibody; CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_HUMAN; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha; anti-IL-4R antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Specificity: IL-4R polyclonal Antibody detects endogenous levels of IL-4R protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-IL-4R antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from rat IL-4R:111-210/801
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Anti- IL-4R at 1/1000 dilution)

Testing Data

(Anti- IL-4R at 1/1000 dilution)

Testing Data

(Anti- IL-4R at 1/1000 dilution)

Related Product Information for anti-IL-4R antibody

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

NCBI and Uniprot Product Information

• NCBI GI #: 158534071
• NCBI GeneID: 25084
• NCBI Accession #: NP_596871.2
• NCBI GenBank Nucleotide #: NM_133380.2
• UniProt Accession #: Q63257; Q9R1W8; Q9WTM8
• Molecular Weight: 26,001 Da
• NCBI Official Full Name: interleukin-4 receptor subunit alpha
• NCBI Official Synonym Full Names: interleukin 4 receptor
• NCBI Official Symbol: Il4r
• NCBI Official Synonym Symbols: Il4ra
• NCBI Protein Information: interleukin-4 receptor subunit alpha
• UniProt Protein Name: Interleukin-4 receptor subunit alpha
• UniProt Gene Name: Il4r
• UniProt Synonym Gene Names: Il4ra; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA

NCBI Description

a receptor for the cytokine IL-4 [RGD, Feb 2006]

Uniprot Description

IL4R: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 1q36

Cellular Component: extracellular space; integral component of membrane; plasma membrane; receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein heterodimerization activity

Biological Process: cytokine-mediated signaling pathway; defense response to protozoan; immune response; immunoglobulin mediated immune response; inflammatory response; negative regulation of T-helper 1 cell differentiation; ovulation; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation; positive regulation of T-helper 2 cell differentiation; production of molecular mediator of acute inflammatory response; regulation of cell proliferation; response to estrogen