Western Blot (WB)
(Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 μg/ml in (A) the presence and (B) the absence of blocking peptide.)
Rabbit anti-Human IL-37 Polyclonal Antibody | anti-IL37 antibody
IL-37 Antibody
Western Blot (WB)
(Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 μg/ml in (A) the presence and (B) the absence of blocking peptide.)
Western Blot (WB)
(Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 μg/ml in (A) the presence and (B) the absence of blocking peptide.)
Immunohistochemistry (IHC)
(Immunohistochemistry of IL-12A in human kidney tissue with IL-12A antibody at 5 μg/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of IL-12A in human kidney tissue with IL-12A antibody at 5 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of IL-12A in human kidney tissue with IL-12A antibody at 20 μg/mL.)
Immunofluorescence (IF)
(Immunofluorescence of IL-12A in human kidney tissue with IL-12A antibody at 20 μg/mL.)
NCBI and Uniprot Product Information
Observed: 23kDa
NCBI Description
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 2q12-q14.1
Cellular Component: nucleoplasm; extracellular space; cytoplasm; nucleolus; extracellular region; nucleus; cytosol
Molecular Function: interleukin-1 receptor binding; cytokine activity
Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response
Research Articles on IL37
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Product Notes
The IL37 il37 (Catalog #AAA153344) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-37 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IL-37 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). IL-37 antibody can be used for detection of IL-37 by Western blot at 1 - 2 mug/ml. Researchers should empirically determine the suitability of the IL37 il37 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-37, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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