Western Blot (WB)
(Western Blot (WB) analysis of IL-22Ralpha2 polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse heart tissue lysateLane3:Rat heart tissue lysate)
Rabbit IL-22Ralpha2 Polyclonal Antibody | anti-IL-22Ralpha2 antibody
IL-22Ralpha2 Polyclonal Antibody
Gene Names
IL22RA2; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
IL-22Ralpha2; Polyclonal Antibody; IL-22Ralpha2 Polyclonal Antibody; Interleukin-22 receptor subunit alpha-2; IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; CRF2-10; Cytokine receptor family type 2; soluble 1; CRF2-S1; Interleukin-22-binding protein; IL-22BP; IL22BP; ZcytoR16; IL22RA2; UNQ5793/PRO19598/PRO19822; anti-IL-22Ralpha2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
IL-22Ralpha2 polyclonal antibody detects endogenous levels of IL-22Ralpha2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
231
Applicable Applications for anti-IL-22Ralpha2 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:1000
Immunogen
A synthetic peptide corresponding to residues in Human IL-22Ralpha2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of IL-22Ralpha2 polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse heart tissue lysateLane3:Rat heart tissue lysate)
Western Blot (WB)
(Western Blot (WB) analysis of IL-22Ralpha2 polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse heart tissue lysateLane3:Rat heart tissue lysate)
Related Product Information for anti-IL-22Ralpha2 antibody
IL-22Ralpha2 (interleukin-22 receptor alpha-2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2 soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22Ralpha2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is four- to ten-fold higher than that of the membrane bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22Ralpha2 prevents the binding to the IL-22 membrane bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22Ralpha2 may be important in regulating inflammatory responses. In addition, IL-22Ralpha2 can be induced by lipopolysaccharide (LPS).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 30kDa
NCBI Official Full Name
interleukin-22 receptor subunit alpha-2 isoform 2
NCBI Official Synonym Full Names
interleukin 22 receptor subunit alpha 2
NCBI Official Symbol
IL22RA2
NCBI Official Synonym Symbols
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
NCBI Protein Information
interleukin-22 receptor subunit alpha-2
UniProt Protein Name
Interleukin-22 receptor subunit alpha-2
UniProt Gene Name
IL22RA2
UniProt Synonym Gene Names
IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; IL22BP
UniProt Entry Name
I22R2_HUMAN
NCBI Description
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Research Articles on IL-22Ralpha2
Similar Products
Product Notes
The IL-22Ralpha2 il22ra2 (Catalog #AAA3006544) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL-22Ralpha2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IL-22Ralpha2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the IL-22Ralpha2 il22ra2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-22Ralpha2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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