Rabbit anti-Human, Mouse IL-17 Polyclonal Antibody | anti-IL17A antibody

IL-17 Antibody

Cat. Num. AAA150637

• Gene Names: IL17A; IL17; CTLA8; IL-17; IL-17A
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: IL-17 Antibody is affinity chromatography purified via peptide column.
• Synonyms: IL-17; Polyclonal Antibody; IL-17 Antibody; IL17; CTLA8; IL-17A; Interleukin-17A; Cytotoxic T-lymphocyte-associated antigen 8; interleukin 17A; anti-IL17A antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: IL-17 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 155

• Applicable Applications for anti-IL17A antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: IL-17 antibody can be used for the detection of IL-17 by Western blot at 1 - 2 mug/ml
• Conjugate: Unconjugated
• Immunogen: IL-17 antibody was raised against a 19 amino acid synthetic peptide from near the center of human IL-17A.
• Buffer: IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IL-17 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of 1 ng of recombinant human IL-17 with IL-17 antibody at 1 μg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of IL-17 in human tonsil tissue with IL-17 antibody at 5 μg/ml.)

Immunofluorescence (IF)

(Immunofluorescence of IL-17 in human tonsil tissue with IL-17 antibody at 20 μg/ml.Green: IL-17 Antibody (4887)Blue: DAPI staining)

Immunohistochemistry (IHC)

(Immunohistochemistry of IL-17 in mouse colon tissue with IL-17 antibody at 2 μg/ml.)

Immunofluorescence (IF)

(Immunofluorescence of IL-17 in A-20 cells with IL-17 antibody at 5 μg/ml.Green: IL-17 Antibody (4887)Blue: DAPI staining)

Immunofluorescence (IF)

(Immunofluorescence of IL-17 in mouse thymus tissue with IL-17 Antibody at 20 μg/mL.)

Related Product Information for anti-IL17A antibody

IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

NCBI and Uniprot Product Information

• NCBI GI #: 4504651
• NCBI GeneID: 3605
• NCBI Accession #: NP_002181
• NCBI GenBank Nucleotide #: NM_002190.2
• UniProt Accession #: Q16552; Q5T2P0
• Molecular Weight: 17,504 Da
• NCBI Official Full Name: interleukin-17A
• NCBI Official Synonym Full Names: interleukin 17A
• NCBI Official Symbol: IL17A
• NCBI Official Synonym Symbols: IL17; CTLA8; IL-17; IL-17A
• NCBI Protein Information: interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
• UniProt Protein Name: Interleukin-17A
• Protein Family: Interleukin
• UniProt Gene Name: IL17A
• UniProt Synonym Gene Names: CTLA8; IL17; IL-17; IL-17A; CTLA-8
• UniProt Entry Name: IL17_HUMAN

NCBI Description

The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Uniprot Description

IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function: cytokine activity

Biological Process: cell death; cell-cell signaling; positive regulation of osteoclast differentiation; apoptosis; positive regulation of interleukin-23 production; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response