Rabbit IL-11Ralpha Polyclonal Antibody | anti-IL-11Ralpha antibody

IL-11Ralpha (D361) Polyclonal Antibody

Cat. Num. AAA3013886

• Gene Names: IL11RA; CRSDA
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: IL-11Ralpha; Polyclonal Antibody; IL-11Ralpha (D361) Polyclonal Antibody; Interleukin-11 receptor subunit alpha; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA; IL11RA; anti-IL-11Ralpha antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IL-11Ralpha(D361) polyclonal antibody detects endogenous levels of IL-11Ralpha protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 422

• Applicable Applications for anti-IL-11Ralpha antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 330-380 of Human IL-11Ralpha.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of IL-11Ralpha (D361) pAb at 1:500 dilutionLane1:A375 whole cell lysate (40ug) Lane2:K562 whole cell lysate (40ug) Lane3:The Muscle tissue lysate of Mouse (30ug) Lane4:The Heart tissue lysate of Rat (30ug))

Related Product Information for anti-IL-11Ralpha antibody

The pleiotropic cytokine, IL-11, has been shown to have proliferative and differentiation effects on lymphopoietic, myeloid and erythroid cells. IL-11 also has the inhibiting effect of repressing adipogenesis in vitro. The IL-11alpha receptor, IL-11Ralpha, is a member of the class 1 subgroup of the cytokine receptor family and exhibits structural similarity to the alpha subunits of the human ciliary neurotrophic factor (CNTF) and the mouse IL-6 receptor. It is speculated that the IL-11Ralpha regulates the proliferation and/or differentiation of skeletogenic progenitor and mesenchymal cells. Coexpression of gp130 and IL-11alpha is necessary for high-affinity binding of IL-11 to IL-11Ralpha. It has also been found that coexpression of IL-11Ralpha and gp130 is required for proper stimulation of Ba/F3 cells to differentiate into macrophage in response to IL-11.

NCBI and Uniprot Product Information

• NCBI GI #: 218505839
• NCBI GeneID: 3590
• NCBI Accession #: NP_001136256.1
• NCBI GenBank Nucleotide #: NP_001136256.1
• UniProt Accession #: Q14626
• Molecular Weight: ~ 45kDa
• NCBI Official Full Name: interleukin-11 receptor subunit alpha
• NCBI Official Synonym Full Names: interleukin 11 receptor subunit alpha
• NCBI Official Symbol: IL11RA
• NCBI Official Synonym Symbols: CRSDA
• NCBI Protein Information: interleukin-11 receptor subunit alpha
• UniProt Protein Name: Interleukin-11 receptor subunit alpha
• UniProt Gene Name: IL11RA
• UniProt Synonym Gene Names: IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA
• UniProt Entry Name: I11RA_HUMAN

NCBI Description

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Description

IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: integral to plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; developmental process; signal transduction; embryo implantation

Disease: Craniosynostosis And Dental Anomalies