Western Blot (WB)
(Western blot analysis IGF2R (Phospho-Ser2484) using EGF treated 293 whole cell lysates)
Rabbit IGF2R Polyclonal Antibody | anti-IGF2R antibody
IGF2R (Phospho-Ser2484) Antibody
Western Blot (WB)
(Western blot analysis IGF2R (Phospho-Ser2484) using EGF treated 293 whole cell lysates)
Western Blot (WB)
(Western blot analysis IGF2R (Phospho-Ser2484) using EGF treated 293 whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Uniprot Description
IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.
Protein type: Membrane protein, integral; Receptor, misc.; Vesicle
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: cell surface; early endosome; endocytic vesicle; endosome; focal adhesion; integral to plasma membrane; late endosome; membrane; trans-Golgi network; trans-Golgi network membrane; trans-Golgi network transport vesicle; transport vesicle
Molecular Function: glycoprotein binding; identical protein binding; insulin-like growth factor receptor activity; phosphoprotein binding; protein binding; receptor activity
Biological Process: receptor-mediated endocytosis; signal transduction
Disease: Hepatocellular Carcinoma
Research Articles on IGF2R
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Product Notes
The IGF2R igf2r (Catalog #AAA9416531) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IGF2R (Phospho-Ser2484) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IGF2R can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000. Researchers should empirically determine the suitability of the IGF2R igf2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IGF2R, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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