Immunohistochemistry (IHC)
(Researcher:Haodong Xu. Department of Pathology, University of Rochester medical CenterApplication: IHCSpecies+tissue/cell type: Human small intestinePrimary antibody dilution: 1:300Secondary antibody: Anti-rabbit-linker, Fbex-HRP)
Rabbit IGF2BP1 Polyclonal Antibody | anti-IGF2BP1 antibody
IGF2BP1 antibody - N-terminal region
Immunohistochemistry (IHC)
(Researcher:Haodong Xu. Department of Pathology, University of Rochester medical CenterApplication: IHCSpecies+tissue/cell type: Human small intestinePrimary antibody dilution: 1:300Secondary antibody: Anti-rabbit-linker, Fbex-HRP)
Immunohistochemistry (IHC)
(Researcher:Haodong Xu. Department of Pathology, University of Rochester medical CenterApplication: IHCSpecies+tissue/cell type: Human small intestinePrimary antibody dilution: 1:300Secondary antibody: Anti-rabbit-linker, Fbex-HRP)
Immunohistochemistry (IHC)
(Sample Type :Human lung carcinomaPrimary Antibody Dilution :1:300Secondary Antibody :Anti-rabbit-linker, Fbex-HRPSecondary Antibody Dilution :NOT FOUNDColor/Signal Descriptions :Brown: IGFBP1 Blue: NucleiGene Name :IGF2BP1Submitted by :Haodong Xu. Department of Pathology, University of Rochester medical Center )
Immunohistochemistry (IHC)
(Sample Type :Human lung carcinomaPrimary Antibody Dilution :1:300Secondary Antibody :Anti-rabbit-linker, Fbex-HRPSecondary Antibody Dilution :NOT FOUNDColor/Signal Descriptions :Brown: IGFBP1 Blue: NucleiGene Name :IGF2BP1Submitted by :Haodong Xu. Department of Pathology, University of Rochester medical Center )
Western Blot (WB)
(Host: MouseTarget Name: IGF2BP1Sample Tissue: Mouse PancreasAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: MouseTarget Name: IGF2BP1Sample Tissue: Mouse PancreasAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IGF2BP1Sample Tissue: Human 721_BAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IGF2BP1Sample Tissue: Human 721_BAntibody Dilution: 1.0ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IGF2BP1Sample Tissue: Human A549 Whole CellAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IGF2BP1Sample Tissue: Human A549 Whole CellAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IGF2BP1Sample Tissue: Mouse PancreasAntibody Dilution: 1ug/ml)
Western Blot (WB)
(Host: RabbitTarget Name: IGF2BP1Sample Tissue: Mouse PancreasAntibody Dilution: 1ug/ml)
Western Blot (WB)
(WB Suggested Anti-IGF2BP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate)
Western Blot (WB)
(WB Suggested Anti-IGF2BP1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate)
Target Description: IGF2BP1 is a member of the IGF-II mRNA-binding protein (IMP) family. The protein contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation.This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Uniprot Description
IGF2BP1: a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: growth cone; perinuclear region of cytoplasm; stress granule; axon; lamellipodium; cytoplasm; dendritic spine; ribonucleoprotein complex; cytosol; nucleus; filopodium
Molecular Function: mRNA binding; protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding
Biological Process: mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process
Research Articles on IGF2BP1
Similar Products
Product Notes
The IGF2BP1 igf2bp1 (Catalog #AAA3213866) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IGF2BP1 antibody - N-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's IGF2BP1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the IGF2BP1 igf2bp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: AFVDCPDEHW AMKAIETFSG KVELQGKRLE IEHSVPKKQR SRKIQIRNIP P. It is sometimes possible for the material contained within the vial of "IGF2BP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
